Learning and mother-infant relationship based on the fetal memory in the newborn

基于新生儿胎儿记忆的学习和母婴关系

• 批准号: 12610078
• 负责人: KODAMA Noriko
• 金额: $ 2.24万
• 依托单位: Shiga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12610078/
• 关键词: cesarean delivery; mother's milk; amniotic fluid; attachment; 初乳; マウス; プロラクチン

Mother's ventral fur, wet with amniotic fluid and ejected milk, stimulates the oral area of the newborn pup before the initial nipple grasp response in many mammals. The newborn pup receives these stimuli, probes the mother's fur, searches the nipple, and attaches it. It is hypothetized that the newborn pup memorizes characteristics of amniotic fluid, and that it associates the familiar amniotic fluid with novel stimulus, mother's milk, immediately after birth and responds to these stimuli. The aim of this study was to investigate the relationship between these stimuli and body movements in the cesarean-delivered mouse pups.The amniotic fluid obtained from pregnant females of Slc : ICR mice and mother's milk from the naturally parturient mothers were kept at 70℃ until the experiment. The fur brush was made of fur collected from around the nipple area of a donor female. Three hours after cesarean delivery each pup was tested for 9 minutes. In the baseline session, spontaneous body movements of pups were observed. In the odor presentation session, the fur brush wet with amniotic fluid, mother's milk, saline, and distilled water, was presented in front of the pup's nose. In the stimulation session, the perioral area of pups was stimulated with the brush.When the perioral area was stimulated with the fur brush and amniotic fluid, head extension and up-down movements, mouth movement, and rearlimb movement increased. Mother's milk on Day 0 had a little effect on these movements, but that on Day 3 had no specific effect. It indicates that the amniotic fluid familiar in prenatal period plays an important role for newborns to locate and attach the mother, and that the mother's milk, a novel stimulus, would be associated with the fluid and have the effect on attachment.

在许多哺乳动物中，母亲的腹部皮毛被羊水和喷出的乳汁润湿，在最初的乳头抓握反应之前刺激新生幼崽的口腔区域。新生的幼犬接受这些刺激，探测母亲的皮毛，寻找乳头，并将其附着。据推测，新生的幼犬记住了羊水的特征，并在出生后立即将熟悉的羊水与新的刺激（母乳）联系起来，并对这些刺激做出反应。本研究将Slc：ICR小鼠妊娠母鼠的羊水和自然分娩母鼠的乳汁在70℃下保存，观察这些刺激与剖腹产仔鼠身体运动的关系。毛刷由从供体雌性的乳头区域周围收集的毛皮制成。剖腹产后3小时，对每只幼仔进行9分钟测试。在基线阶段，观察到幼仔的自发身体运动。在气味呈现阶段，将用羊水、母乳、盐水和蒸馏水润湿的毛刷呈现在幼犬的鼻子前面。在刺激阶段，用毛刷刺激幼鼠口周区域，当用毛刷和羊水刺激口周区域时，头部伸展和上下运动、嘴运动和后肢运动增加。第0天的母乳对这些运动有一点影响，但第3天的母乳对这些运动没有特别的影响。这表明，胎儿期熟悉的羊水对新生儿定位和依恋母亲起着重要作用，而母乳作为一种新的刺激物，可能与羊水相联系，对依恋产生影响。

项目成果

児玉典子: "母親の体毛刺激に対する帝王切開された胎児の反応"日本心理学会第64回大会発表論文集. 951 (2000)

Noriko Kodama：“剖腹产胎儿对母体毛发刺激的反应”日本心理学会第 64 届年会记录 951 (2000)。

Noriko Kodama: "Effects of odor and taste of amniotic fluid and mother's milk on body movements in newborn mice"Developmental Psychobiology. 41-3. 310 (2002)

Noriko Kodama：“羊水和母乳的气味和味道对新生小鼠身体运动的影响”发育心理生物学。

Noriko Kodama: "The role of mother's fur, amniotic fluid and mother's milk in nipple attachment in mice"17^<th> Biennial Meeting of International Society for the Study of Behavioural Development. (CD-ROM). (2002)

Noriko Kodama：“母亲的皮毛、羊水和母乳在小鼠乳头附着中的作用”，国际行为发展研究学会第十七届双年度会议。

児玉典子: "母親の羊水・母乳・体毛に対する帝王切開された胎児の反応"日本心理学会第65回大会発表論文集. 599 (2001)

Noriko Kodama：“剖宫产胎儿对母亲羊水、母乳和体毛的反应”第 65 届日本心理学会年会记录 599 (2001)。

Noriko Kodama: "Responses of cesarean delivered fetus to amniotic fluid, mother's milk and mother's fur"The 65^<th> Annual Meeting of Japanese Psychological Asscociation. 599 (2001)

儿玉法子：“剖腹产胎儿对羊水、母乳、母毛的反应”第65届日本心理学会年会。