CALCIUM ABSORPTION IN NEONATES FED WITH MOTHER'S MILK FORTIFIED WITH A DONOR

用捐赠者强化母乳喂养的新生儿的钙吸收

• 批准号: 8166693
• 负责人: STEVEN A ABRAMS
• 金额: $ 0.3万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166693
• 关键词: Body Composition; Bone Growth; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Grant; Growth; Human Milk; Infant; Institution; Milk; Minerals; Mothers; Neonatal; Nutrient; Outcome; Physiologic calcification; Premature Infant; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Very Low Birth Weight Infant; base; calcium absorption; feeding; neonate; nutrition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast milk is considered the nutrition of choice for infants, including premature infants in the Neonatal ICU (NICU). In the case of very low birth weight (VLBW) infants, this milk is generally supplemented with a human milk fortifier (HMF) in order to provide the additional nutrients that these babies require. We propose to investigate a HMF made from pasteurized donor human milk, in particular regarding calcium absorption, growth, bone mineral status, body composition, and feeding tolerance. We hypothesize that these study parameters will result in adequate outcomes with the use of the donor milk based HMF. The use of a human milk fortifier made from pasteurized donor human milk will provide adequate calcium absorption to preterm infants. In addition, this new fortifier will provide adequate growth and bone mineralization. Primary Aim: To determine calcium absorption in premature infants fed mother''s own milk fortified with pasteurized donor human milk fortifier. Secondary Aims: (1) To evaluate the growth, bone mineral status, and body composition of premature infants fed mother''s own milk fortified with pasteurized donor human milk fortifier, and, (2) To assess feeding tolerance (pilot data) in infants fed mother''s own milk fortified with pasteurized donor human milk.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 母乳被认为是婴儿的营养选择，包括新生儿ICU（NICU）中的早产儿。在极低出生体重（VLBW）婴儿的情况下，这种牛奶通常补充有人乳强化剂（HMF），以提供这些婴儿所需的额外营养。我们建议研究由巴氏灭菌供体人乳制成的HMF，特别是关于钙吸收、生长、骨矿物质状态、身体组成和喂养耐受性。我们假设，这些研究参数将导致使用供体乳汁为基础的HMF的充分结果。 使用由巴氏灭菌的供体人乳制成的人乳强化剂将为早产儿提供足够的钙吸收。此外，这种新的强化剂将提供足够的生长和骨矿化。 主要目的：测定早产儿喂养经巴氏灭菌供体人乳强化剂强化的母乳的钙吸收。 次要目标：（1）评价喂养用巴氏灭菌供体人乳强化剂强化的母乳的早产儿的生长、骨矿物质状态和身体组成，（2）评估喂养用巴氏灭菌供体人乳强化的母乳的婴儿的喂养耐受性（试点数据）。