Host-parasite coevolutionary dynamics and the disease control

宿主-寄生虫协同进化动力学和疾病控制

• 批准号: 12640617
• 负责人: SASAKI Akira
• 金额: $ 2.18万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12640617/
• 关键词: coevolution; gene-for-gene interaction; evolution of virulence; development of resistance; spatial structure; cross immunity; couter-evolution-free eradication; vaccine derived strain; 宿主抵抗性; 病原体ビルレンス; 遺伝子対遺伝子相互作用; ポリオ根絶計画; 強毒復帰株; マラリア; 殺虫剤抵

[1] Coevolutionary dynamics of host plant and fungus pathogen uder gene-for-gene interaction is analyzed. The effect of mixed planting of resistant races, and the introduction of multiple resistance against pathogens are theoretically evaluated (Sasaki A, Proc. R, Soc. Lond. B, 2000; Iwanaga A, Sasaki A, in review).Also investigated is the spontaneous asynchrony emerging in the gene-for-gene dynamics in metapopulation (Sasaki A, Hamilton WD, Ubeda F, Proc. R. Soc. Lond. B, 2002).[2] Optimal drug treatment under the development of drug resistance in HIV and pathogenic bacteria is studied taking into account the random drift due to a finite population. The effect of random drift in antigenic drift of HIV in a host is also analyzed using a finite site model for viral epitopes (Haraguchi Y, Sasaki A, J. Mol. Evol., 2000).[3] The probability of re-emergence of vaccine derived virulent virus after the secession of oral polio vaccination is estimated based on the epidemilological dynamics, wa … More ring theoretically that the risk of virulent virus outbreak is quite high (Haraguchi Y, Sasaki A, Yoshida H, Am. J. Epidem. in review).[4] Maralia control strategy is proposed which make use of the zooprolylaxis (the attraction of vector mosquitoes to an dead-end host of malaria). With an intermediate use of insecticide, the malaria can be eradicated without allowing the development of insecticide resistance in mosquitoes (Kawaguchi I, Sasaki A, Mogi M, Proc. R. Soc. Lond. B, in review).[5] A pecuriar phenomena of mortality enhancement at the second infection by dengue viruses is modeled, and its effect on the stable cocirculation of dengue subtypes is analyzed theoretically (Kawaguchi I, Sasaki A, Boots M, Evolution, in review).[6] The effect of spatial structure and the contact network structure ('small world' effect) on the evolution of virulence and the epidemiological dynamics is analyzed (Haraguchi Y, Sasaki A, J. theor. Biol., 2000; Boots M, Sasaki A, Ecology Letters, 2000; Boots M, Sasaki A, Am. Nat., 2002).[7] The multistrain epidemiological dynamics with seasonality and cross-immunity is analyzed to forecast the pattern of epidemic outbreaks (Kamo M, Sasaki A, Physica D, 2002). Less

分析了寄主植物与真菌病原菌在基因对基因互作下的协同进化动力学。从理论上评价了抗病小种混合种植的效果，以及引入多种抗病病原菌的效果(Sasaki A, Proc. R, Soc。Lond。B, 2000;Iwanaga A, Sasaki A, in review)。此外，还研究了元种群中基因对基因动态中出现的自发异步（Sasaki A, Hamilton WD, Ubeda F, Proc. R. Soc）。Lond。B, 2002)。[2]在考虑有限种群随机漂移的情况下，研究了HIV和病原菌耐药发展的最佳药物治疗方案。随机漂移对宿主内HIV抗原漂移的影响也使用病毒表位的有限位点模型进行了分析（Haraguchi Y, Sasaki a， J. Mol. evolution .）。, 2000)。[3]口服脊髓灰质炎疫苗接种结束后，根据流行病学动态估计疫苗衍生强毒病毒再次出现的可能性。更重要的是，理论上强毒病毒爆发的风险相当高(Haraguchi Y, Sasaki A, Yoshida H, Am。j . Epidem。在回顾)。[4]提出了利用zooprolylaxis（蚊媒吸引疟疾死角宿主）控制疟疾的策略。通过中间使用杀虫剂，可以在不使蚊子产生杀虫剂抗性的情况下根除疟疾(Kawaguchi I, Sasaki A, Mogi M, Proc. R. Soc。Lond。B，在复习中模拟了登革热病毒第二次感染时死亡率增加的奇特现象，并从理论上分析了其对登革热亚型稳定共循环的影响（Kawaguchi I, Sasaki A, Boots M, Evolution, in review）分析了空间结构和接触网络结构（“小世界”效应）对毒力演变和流行病学动态的影响（Haraguchi Y, Sasaki A， J. thether）。医学杂志。, 2000;Boots M, Sasaki A，生态学快报，2000；Boots M, Sasaki A, Am。Nat。,2002年)。[7]分析了具有季节性和交叉免疫的多株流行病学动态，以预测流行病暴发的模式（Kamo M, Sasaki A, Physica D, 2002）。少

项目成果

Boots,M.and A.Sasaki.: "Why are insect diseases so virulent? the evolutionary dynamics of local infection and global reproduction in host-parasite interactions"Ecology Letters. 3. 181-185 (2000)

Boots, M. 和 A. Sasaki.：“为什么昆虫疾病如此致命？宿主与寄生虫相互作用中局部感染和全球繁殖的进化动态”《生态快报》。

Kamo M., Sasaki A.: "The effect of cross-immunity and seasonal forcing in multi-strain epidemic model"Physiea D.. (in press).

Kamo M.、Sasaki A.：“多菌株流行病模型中交叉免疫和季节性强迫的影响”Physiea D..（出版中）。

Satake A., Sasaki A., Iwasa Y.: "Variable timing of reproduction in unpredictable environments:adaptation of flood plain plants"Theor. Pop. Biol.. 60. 1-15

Satake A.、Sasaki A.、Iwasa Y.：“不可预测环境中繁殖的可变时间：洪泛区植物的适应”理论。

Sasaki A: "Host-parasite coevolution in multilocus gene-for-gene system"Proc. Roy. Soc. Lond. B. 267. 2183-2188 (2000)

Sasaki A：“多位点基因对基因系统中的宿主-寄生虫共同进化”Proc。

Sasaki A., Kawaguchi I., Yoshimori A.: "Spatial mosaic and interfacial dynamics in Mullerian mimicry system"Theor. Pop. Biol.. (in press).

Sasaki A.、Kawaguchi I.、Yoshimori A.：“缪勒拟态系统中的空间镶嵌和界面动力学”理论。