Host-parasite coevolutionary dynamics and the disease control

[1]分析了基因对基因相互作用下寄主植物和真菌病原菌的协同进化动力学。从理论上评估了混合种植抗性小种的效果，以及对病原菌的多重抗性的引入(Sasaki A，Proc.R、Soc.朗德。B，2000；Iwanaga A，Sasaki A，回顾中)。还研究了集合种群中基因对基因动力学中出现的自发异步性(Sasaki A，Hamilton WD，Ubeda F，Proc.R.Soc.朗德。B，2002)。[2]在考虑到有限人群的随机漂移的情况下，研究了艾滋病毒和病原菌中耐药性发展下的最优药物治疗。还使用病毒表位的有限位置模型(Haraguchi Y，Sasaki A，J.Mol)分析了宿主中HIV抗原漂移中的随机漂移的影响。[3]基于流行病学动力学，Wa…估计了脱离口服脊髓灰质炎疫苗接种后疫苗衍生的强毒病毒再次出现的可能性。从理论上讲，强病毒爆发的风险相当高(Haraguchi Y，Sasaki A，Yoshida H，AmJ.Epidem。[4]提出了利用动物致病作用(媒介蚊子对疟疾死角宿主的吸引)的疟疾防治策略。通过中间使用杀虫剂，可以在不允许蚊子产生抗药性的情况下根除疟疾(Kawaguchi I，Sasaki A，Mogi M，Proc.R.Soc.朗德。[5]模拟了登革热病毒二次感染时死亡率增加的金融现象，并从理论上分析了它对登革热亚型稳定共循环的影响(川口I，佐佐木A，布茨M，进化)。[6]分析了空间结构和接触网络结构(小世界效应)对毒力进化和流行病学动态的影响(Haraguchi Y，Sasaki A，J.Theor)。Biol.，2000；Boots M，Sasaki A，生态通讯，2000；Boots M，Sasaki A，Am[7]分析了具有季节性和交叉免疫性的多毒株流行病学动态，以预测疫情暴发的模式(Kamo M，Sasaki A，Physica D，2002)。较少

[1] Coevolutionary dynamics of host plant and fungus pathogen uder gene-for-gene interaction is analyzed. The effect of mixed planting of resistant races, and the introduction of multiple resistance against pathogens are theoretically evaluated (Sasaki A, Proc. R, Soc. Lond. B, 2000; Iwanaga A, Sasaki A, in review).Also investigated is the spontaneous asynchrony emerging in the gene-for-gene dynamics in metapopulation (Sasaki A, Hamilton WD, Ubeda F, Proc. R. Soc. Lond. B, 2002).[2] Optimal drug treatment under the development of drug resistance in HIV and pathogenic bacteria is studied taking into account the random drift due to a finite population. The effect of random drift in antigenic drift of HIV in a host is also analyzed using a finite site model for viral epitopes (Haraguchi Y, Sasaki A, J. Mol. Evol., 2000).[3] The probability of re-emergence of vaccine derived virulent virus after the secession of oral polio vaccination is estimated based on the epidemilological dynamics, wa … More ring theoretically that the risk of virulent virus outbreak is quite high (Haraguchi Y, Sasaki A, Yoshida H, Am. J. Epidem. in review).[4] Maralia control strategy is proposed which make use of the zooprolylaxis (the attraction of vector mosquitoes to an dead-end host of malaria). With an intermediate use of insecticide, the malaria can be eradicated without allowing the development of insecticide resistance in mosquitoes (Kawaguchi I, Sasaki A, Mogi M, Proc. R. Soc. Lond. B, in review).[5] A pecuriar phenomena of mortality enhancement at the second infection by dengue viruses is modeled, and its effect on the stable cocirculation of dengue subtypes is analyzed theoretically (Kawaguchi I, Sasaki A, Boots M, Evolution, in review).[6] The effect of spatial structure and the contact network structure ('small world' effect) on the evolution of virulence and the epidemiological dynamics is analyzed (Haraguchi Y, Sasaki A, J. theor. Biol., 2000; Boots M, Sasaki A, Ecology Letters, 2000; Boots M, Sasaki A, Am. Nat., 2002).[7] The multistrain epidemiological dynamics with seasonality and cross-immunity is analyzed to forecast the pattern of epidemic outbreaks (Kamo M, Sasaki A, Physica D, 2002). Less