Study on a smell communication system using integrated bio-devices

利用集成生物器件的气味通讯系统的研究

• 批准号: 12650396
• 负责人: MITSUBAYASHI Kohji
• 金额: $ 2.56万
• 依托单位: TOKAI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650396/
• 关键词: bio-device; sensory test; bio-sniffer; smell communication; smell reproducer; optical fiber; enzyme; nose; 光ファイバー型; 薬物代謝; 匂いセンサ; アンモニアガス; メチルメルカプタン; 匂い再生; 光ファイバーセンサ; アルデヒドガス; トリメチルアミン; 集積化デバイス

A newly smell communication system with analyzing and reproducing chemical constituents of smell was investigated with three steps, (A) Constructions of biochemical gas-sensors and nose system with high gas-selectivity, (B) Fabrication of a smell regenerator, (C) Construction and sensory evaluation of the smell communication system. The detailed results are described as follows.(A) Several kinds of biochemical gas-sensors (bio-device, bio-sniffer) were developed by immobilizing biological catalysts (enzyme) onto sensing tip of dissolved oxygen electrode, screen printed electrodes and oxygen sensitive optical fibers. Detectable gas-substances: ethanol, dimethyl sulfide, trimethylamine, methyl mercaptan, ammonia, acetaldehyde, formaldehyde, etc.(B) The smell reproducer for typical smell constituents, ethanol (alcohol-), trimethylamine (fish-), methyl mercaptan (radish-) and dimethyl sulfide(seaweed-odor substance), was fabricated using 2 x 2ch gas-generators (totally 4ch).(C) The smell communication system for the above mentioned constituents was constructed by connecting (A) the bio-nose with (B) the gas-reproducer. The system was applied for smell communications of food and drink (alcohol, fish, radish and seaweed), and evaluated by the sensory test with healthy male subjects, thus obtained over 80% of smell transmissibility.

本研究通过三个步骤，即（A）高气体选择性的生化气体传感器和鼻系统的构建，（B）气味再生器的制作，（C）气味交流系统的构建和感官评价，研究了一种新的气味交流系统。详细结果描述如下。(A)通过将生物催化剂（酶）固定在溶氧电极、丝网印刷电极和氧敏光纤的敏感尖端上，研制了几种生化气体传感器（生物器件、生物嗅探器）。可检测气体物质：乙醇、二甲硫醚、三甲胺、甲基异丙胺、氨、乙醛、甲醛等。(B)用2 × 2ch气体发生器（共4ch）制作了典型气味成分乙醇（醇-）、三甲胺（鱼-）、甲基硫醚（萝卜-）和二甲基硫醚（海藻气味物质）的气味再现器。(C)通过连接（A）生物鼻与（B）气体再生器来构建上述成分的气味通信系统。该系统应用于食物和饮料（酒精，鱼，萝卜和海藻）的气味通信，并通过健康男性受试者的感官测试进行评估，从而获得80%以上的气味传递率。

项目成果

Kohji MITSUBAYASHI: "Bioelectronic nose with xenobiotic metabolizing system for malodor substances"40th Eastern Analytical Symposium & Exposition, ABSTRACTS. 64 (2001)

Kohji MITSUBAYASHI：“具有针对恶臭物质的异生物质代谢系统的生物电子鼻”第40届东方分析研讨会

Kohji MITSUBAYASHI, et. al: "Development of a Gas-Phase Biosensor for Trimethylamine using a Flavin-Containing Monooxygenase 3"Electrochemistry. 68(11). 901-903 (2000)

三林浩司等

Hidenori WATANABE, Kohji MITSUBAYASHI, et. al.: "Gas-phase biosensor for aldehyde chemicals"Journal of Advanced Science. 13(1&2). 29-30 (2001)

渡边秀德、三林浩司等

Yuki HASHIMOTO: "Study of a bioelectronic nose with a drug metabolizing system"Chemical Sensors. 16(B). 52-54 (2000)

Yuki HASHIMOTO：“具有药物代谢系统的生物电子鼻的研究”化学传感器。

Kohji MITSUBAYASHI, et. al.: "Bioelectronic nose with xenobiotic metabolizing system for malodor substances"40th Eastern Analytical Symposium & Exposition. ABSTRACTS. 64 (2001)

三林浩司等