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Memory in normal aging and Parkinson's disease: an event-related potential study

正常衰老和帕金森病中的记忆：事件相关电位研究

基本信息

批准号：
12670630
负责人：
TACHIBANA Hisao
金额：
$ 1.28万
依托单位：
HYOGO COLLEGE OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670630/
关键词：
Parkinson's disease memory event-related potential N400 aging

项目摘要

To assess effects of normal aging and Parldnson's disease (PD) on memory, we examined the N400 component of event-related potentials (ERPs) during lexical decision and recognition memory tasks. To elicit ERPs during the lexical decision task, some words were repeated immediately after the initial presentation (2sec), while others Were repeated after five intervening words (12sec) or after 2 to 4minutes. Subjects were required to respond to occasional non words. The mean N400 amplitude was smaller In patients with PD than in young and elderly healthy groups, but there was no difference between the two healthy groups. In both healthy groups, N400 was attenuated for repeated words. In PD patients, attenuation was noted only for immediate repetitions. For the recognition memory task, words were repeated Immediately after Initial presentation (3sec), while others were repeated after one Intervening word (6sec) or six Intervening words (21sec). Subjects were requested to push a button with the right thumb upon first presentation of a word and with the left thumb upon repeat presentation. Compared to the young healthy group, elderly group showed reduced accuracy In recognizing repeated words after 3 and 21 sec. Compared to elderly healthy group, PD patients showed decreased accuracy in recognizing repeated words after 21 sec. PD patients showed lower N400 amplitudes than elderly healthy subjects. The N400 In the young group showed attenuation for all repetitions, while attenuations In the elderly group andTO group were noted only for repeated words after 3 and6sec. These data suggest that in normal aging, Implicit memory assessed by the lexical decision task is relatively preserved compared to explicit memory, while both implicit and explicit memory functions were Impaired in patients with PD. In addition, memory deficits in PD may result, at least partly from the Impairment of context integration process.

为了评估正常衰老和帕金森病（PD）对记忆的影响，我们研究了词汇决策和再认记忆任务中的事件相关电位（ERPs）的N400成分。在词汇判断任务中，有些词在初始呈现后立即重复（2sec），而另一些词在5个词后重复（12 sec）或在2 - 4 min后重复。受试者被要求对偶尔的非言语做出反应。PD患者的N400平均波幅小于年轻和老年健康组，但两组之间无差异。在两个健康组中，N400对于重复的单词是衰减的。在PD患者中，仅在立即重复时观察到衰减。对于再认记忆任务，单词在初始呈现后立即重复（3sec），而其他单词在一个插入单词（6sec）或六个插入单词（21 sec）后重复。要求受试者在第一次呈现单词时用右手拇指按下按钮，在重复呈现时用左手拇指按下按钮。与年轻健康组相比，老年组在3秒和21秒后对重复单词的识别准确率降低。与老年健康组相比，PD患者在21秒后的重复单词识别准确率下降。PD患者的N400振幅低于老年健康受试者。年轻组N400在所有重复词中都有衰减，而老年组和TO组仅在3秒和6秒后的重复词中有衰减。这些数据表明，在正常的年龄，词汇决策任务评估的内隐记忆相对于外显记忆保存，而PD患者的内隐和外显记忆功能受损。此外，PD患者的记忆缺陷可能至少部分是由于背景整合过程受损所致。