The research of the DNA tip for Autism to analyze the genetic basis

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I studied the genetic basis for autism to development of new diagnostic tool using DNA tip.The conclusions in this study are followings.1. The relation of HTR1A gene which is a serotonin related gene to autism was suggested.2. A specific variation of HOX1A gene was detected only in a few patients with autism.3. I developed a method for find the imprinting gene which is important for molecular mechanism of autism.4. Several mutations of the patients with tuberous sclerosis which is related to autistic behavior were detected.5. I developed the method for the association study using single nucleotide polymorphisms and analysis of the gene expression.The following new projects should be necessary.1. I need more DNA samples from Japanese patients with autism.2. I should developed the new method to find the imprinting genes specific for the brain.3. The functional study of the genes related to autism for developed the new therapeutic method.