MRS and PET imaging of brain tumors : comparative study with pathology and grading

本研究的目的是评价~(11)&gt；C-胆碱PET、~(18)&gt；F-α-甲基酪氨酸、~(18)&gt；F-FDGPET和磁共振波谱(MRS)对脑肿瘤的检出能力和分级。我们还评估了这些方法的有用性。用~(11)&gt；C-胆碱、~(18)&gt；F-α-甲基酪氨酸和~(18)&gt；F-FDGPET研究了裸鼠脑肿瘤的蓄积。比较MRS的胆碱水平和~(11)&gt；C-胆碱的聚集量。我们还检查了脑胶质瘤或脑转移瘤患者的MRS和这些PET研究，这些患者的病因经手术或活检证实。在动物实验和患者中都观察到了几乎类似的发现。18&gt；F-α-甲基酪氨酸正电子发射体层摄影术是发现肿瘤的最佳方法。另一方面，它也不利于肿瘤的分级。~lt；18&gt；F-FDG PET检查与肿瘤分级相关性最好。MRS的胆碱水平与~(11)&GT；C-胆碱PET的肿瘤蓄积无关。它不适用于肿瘤分级。18&gt；F-α-甲基酪氨酸正电子发射体层摄影是一项有用的研究。它有可能用于其他身体肿瘤的成像以及18F-FDG的PET研究。

The aim of this study was to evaluate the detectability and grading of brain tumors using ^<11>C-cholin PET, ^<18>F-α-methyltyrosine PET, ^<18>F-FDG PET, and MR spectroscopy (MRS). We also estimated the usefulness of these methods. The accumulations of the brain tumors of nude mice were measured in ^<11>C-cholin, ^<18>F-α-methyltyrosine and ^<18>F-FDG PET studies. The cholin level of MRS and the accumulation of ^<11>C-cholin PET were compared. We also examined MRS and theses PET studies in patients with gliomas or brain metastases, whose etiologies were confirmed by surgery or biopsy. Almost the similar findings were observed in both animal experiments and patients. ^<18>F-α-methyltyrosine PET study was the best to detect the tumors. On the other hand, it was not good for tumor grading. ^<18>F-FDG PET study showed the best correlation with tumor grading. There were no relationships between the cholin level of MRS and tumor accumulations of ^<11>C-cholin PET. It was not suitable for tumor grading. ^<18>F-α-methyltyrosine PET was a useful study. It has the possibility to be used in other body tumor imagings as well as ^<18>F-FDG PET study.