Relationships between MR diffusion-weighted images, pathology, clinical findings, and genetics in patioents with muscular dystrophy.

肌营养不良症患者的 MR 弥散加权图像、病理学、临​​床表现和遗传学之间的关系。

• 批准号: 17591312
• 负责人: SATO Noriko
• 金额: $ 1.52万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591312/
• 关键词: Myotonic dystrophy; MR; Diffusion-weighted images; Radiology; 拡散強調画像

We have investigated the relationships between clinical and MR imaging findings, especially focusing on intensity changes of diffusion-weighted images of the legs. 25 patients with muscular dystrophy ; 15 patients with myotonic type, 4 patients with Becker type, 6 patients with Lomb-girdle type muscular dystrophy. Their ages were from 15 to 55 years old(mean age ; 36 years old), 17 men and 8 women. T2-weighted images with fat suppression showed multiple or diffuse high signals and diffusion-weighted images represented high signals at the same areas. There were correlations between them. ADC map also showed high intensity, which mean the T2 high signal represented T2 shine-through, probably due to edematous changes. There were correlations between high signals on T2- and diffusion-weighted images and clinical symptoms and serum creatine kinase. The cause of myotonic dystrophy is overextension of CTG(cytosine-thymidine-guanine) trinucleotide on q13.3 of chromosome 19. The number of the triplet extension was not correlated with MR T2 high signals. On the other hand, the patients with muscular dystrophy have a high risk for venous thrombosis of the legs. This study also proved the merit of diffusion-weighted images on MR. Acute thrombosis was shown as bright signal on diffusion-weighted images and low or isointensity on ADC map. It is useful to detect the thrombosis without contrast media which has sometimes induce side effect.

我们研究了临床和 MR 成像结果之间的关系，特别关注腿部扩散加权图像的强度变化。 25名肌营养不良症患者；强直型肌营养不良症15例，Becker型肌营养不良症4例，Lomb-girdle型肌营养不良症6例。年龄15岁至55岁（平均年龄36岁），其中男性17人，女性8人。具有脂肪抑制功能的 T2 加权图像显示多个或弥漫性高信号，而扩散加权图像则表示相同区域的高信号。它们之间存在相关性。 ADC图也显示高强度，这意味着T2高信号代表T2透光，可能是由于水肿变化。 T2 和扩散加权图像上的高信号与临床症状和血清肌酸激酶之间存在相关性。强直性肌营养不良的病因是19号染色体q13.3上的CTG（胞嘧啶-胸苷-鸟嘌呤）三核苷酸过度延伸。三联体延伸的数量与MR T2高信号无关。另一方面，肌营养不良症患者腿部静脉血栓形成的风险较高。这项研究还证明了磁共振扩散加权图像的优点。急性血栓形成在弥散加权图像上显示为亮信号，在 ADC 图上显示为低信号或等信号。无需造影剂即可检测血栓形成，但有时会产生副作用。

项目成果

Magnetic resonance imaging in congenital facial palsy.

先天性面瘫的磁共振成像。

• 发表时间: 2007
• 期刊: Brain Dev. (Epub ahead of print)
• 作者: Sasaki M;Imamura Y;Sato N.
• 通讯作者: Sato N.

Relatiohship between diffusion tensor imaging and brain morphology in patients with myotonic dystiophy.

强直性肌营养不良患者弥散张量成像与脑形态之间的关系。

• 发表时间: 2006
• 期刊: Neuroscience Letters 407
• 作者: Ota M;Sato N;Ohya Y;Aoki Y;Mizukami K;Mori T;Asada T.
• 通讯作者: Asada T.

Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: tract-specific analysis

• DOI: 10.1007/s11604-008-0258-3
• 发表时间: 2008-10-01
• 期刊: RADIATION MEDICINE
• 作者: Nakata, Yasuhiro;Sato, Noriko;Aoki, Shigeki
• 通讯作者: Aoki, Shigeki

MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images:it is useful for differentiation from medulloblastoma?

T2加权图像上毛细胞星形细胞瘤实性部分的MR信号：有助于与髓母细胞瘤鉴别吗？

• 发表时间: 2006
• 期刊: Neuroradiology 48
• 作者: Arai K;Sato N;et. al.
• 通讯作者: et. al.

Uncinate fasciculus in Alzheimer disease:tract specific analysis to measure core of the tract

阿尔茨海默病中的钩束：束特异性分析以测量束的核心

• 发表时间: 2007
• 作者: Hasina Yusumin;中田安浩、青木茂樹、佐藤典子;他
• 通讯作者: 他