Relationships between MR diffusion-weighted images, pathology, clinical findings, and genetics in patioents with muscular dystrophy.

肌营养不良症患者的 MR 弥散加权图像、病理学、临​​床表现和遗传学之间的关系。

• 批准号: 17591312
• 负责人: SATO Noriko
• 金额: $ 1.52万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591312/
• 关键词: Myotonic dystrophy; MR; Diffusion-weighted images; Radiology; 拡散強調画像

We have investigated the relationships between clinical and MR imaging findings, especially focusing on intensity changes of diffusion-weighted images of the legs. 25 patients with muscular dystrophy ; 15 patients with myotonic type, 4 patients with Becker type, 6 patients with Lomb-girdle type muscular dystrophy. Their ages were from 15 to 55 years old(mean age ; 36 years old), 17 men and 8 women. T2-weighted images with fat suppression showed multiple or diffuse high signals and diffusion-weighted images represented high signals at the same areas. There were correlations between them. ADC map also showed high intensity, which mean the T2 high signal represented T2 shine-through, probably due to edematous changes. There were correlations between high signals on T2- and diffusion-weighted images and clinical symptoms and serum creatine kinase. The cause of myotonic dystrophy is overextension of CTG(cytosine-thymidine-guanine) trinucleotide on q13.3 of chromosome 19. The number of the triplet extension was not correlated with MR T2 high signals. On the other hand, the patients with muscular dystrophy have a high risk for venous thrombosis of the legs. This study also proved the merit of diffusion-weighted images on MR. Acute thrombosis was shown as bright signal on diffusion-weighted images and low or isointensity on ADC map. It is useful to detect the thrombosis without contrast media which has sometimes induce side effect.

我们研究了临床和MR成像结果之间的关系，特别是关注腿部弥散加权图像的强度变化。肌肉萎缩症25例；强直型15例，贝克型4例，腰束型肌营养不良6例。年龄15 - 55岁（平均年龄36岁），男性17例，女性8例。脂肪抑制的t2加权图像表现为多发或弥漫性高信号，弥漫性加权图像表现为相同区域的高信号。它们之间存在相关性。ADC图也显示高强度，T2高信号代表T2透光，可能是水肿改变所致。T2和弥散加权高信号与临床症状和血清肌酸激酶有相关性。肌强直性营养不良的病因是19号染色体q13.3上CTG（胞嘧啶-胸腺嘧啶-鸟嘌呤）三核苷酸过伸。三联体延伸数与MR T2高信号无相关性。另一方面，肌肉萎缩症患者下肢静脉血栓形成的风险较高。本研究也证明了弥散加权图像在mr上的优点，急性血栓形成在弥散加权图像上表现为亮信号，在ADC图上表现为低或等强度。不使用造影剂检测血栓是有用的，造影剂有时会引起副作用。

项目成果

Magnetic resonance imaging in congenital facial palsy.

先天性面瘫的磁共振成像。

• 发表时间: 2007
• 期刊: Brain Dev. (Epub ahead of print)
• 作者: Sasaki M;Imamura Y;Sato N.
• 通讯作者: Sato N.

Relatiohship between diffusion tensor imaging and brain morphology in patients with myotonic dystiophy.

强直性肌营养不良患者弥散张量成像与脑形态之间的关系。

• 发表时间: 2006
• 期刊: Neuroscience Letters 407
• 作者: Ota M;Sato N;Ohya Y;Aoki Y;Mizukami K;Mori T;Asada T.
• 通讯作者: Asada T.

Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease: tract-specific analysis

• DOI: 10.1007/s11604-008-0258-3
• 发表时间: 2008-10-01
• 期刊: RADIATION MEDICINE
• 作者: Nakata, Yasuhiro;Sato, Noriko;Aoki, Shigeki
• 通讯作者: Aoki, Shigeki

MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images:it is useful for differentiation from medulloblastoma?

T2加权图像上毛细胞星形细胞瘤实性部分的MR信号：有助于与髓母细胞瘤鉴别吗？

• 发表时间: 2006
• 期刊: Neuroradiology 48
• 作者: Arai K;Sato N;et. al.
• 通讯作者: et. al.

Uncinate fasciculus in Alzheimer disease:tract specific analysis to measure core of the tract

阿尔茨海默病中的钩束：束特异性分析以测量束的核心

• 发表时间: 2007
• 作者: Hasina Yusumin;中田安浩、青木茂樹、佐藤典子;他
• 通讯作者: 他