Relationships between MR diffusion-weighted images, pathology, clinical findings, and genetics in patioents with muscular dystrophy.

肌营养不良症患者的 MR 弥散加权图像、病理学、临​​床表现和遗传学之间的关系。

• 批准号: 17591312
• 负责人: SATO Noriko
• 金额: $ 1.52万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591312/
• 关键词: Myotonic dystrophy; MR; Diffusion-weighted images; Radiology; 拡散強調画像

We have investigated the relationships between clinical and MR imaging findings, especially focusing on intensity changes of diffusion-weighted images of the legs. 25 patients with muscular dystrophy ; 15 patients with myotonic type, 4 patients with Becker type, 6 patients with Lomb-girdle type muscular dystrophy. Their ages were from 15 to 55 years old(mean age ; 36 years old), 17 men and 8 women. T2-weighted images with fat suppression showed multiple or diffuse high signals and diffusion-weighted images represented high signals at the same areas. There were correlations between them. ADC map also showed high intensity, which mean the T2 high signal represented T2 shine-through, probably due to edematous changes. There were correlations between high signals on T2- and diffusion-weighted images and clinical symptoms and serum creatine kinase. The cause of myotonic dystrophy is overextension of CTG(cytosine-thymidine-guanine) trinucleotide on q13.3 of chromosome 19. The number of the triplet extension was not correlated with MR T2 high signals. On the other hand, the patients with muscular dystrophy have a high risk for venous thrombosis of the legs. This study also proved the merit of diffusion-weighted images on MR. Acute thrombosis was shown as bright signal on diffusion-weighted images and low or isointensity on ADC map. It is useful to detect the thrombosis without contrast media which has sometimes induce side effect.

我们已经研究了临床和MR成像发现之间的关系，尤其是重点关注腿部扩散加权图像的强度变化。 25例肌营养不良症患者； 15例肌发电型患者，4例Becker型患者，6例Lomb-Girdle型肌营养不良症患者。他们的年龄为15至55岁（平均年龄； 36岁），17名男性和8名女性。具有脂肪抑制的T2加权图像显示出多个或扩散的高信号，扩散加权图像代表同一区域的高信号。他们之间存在相关性。 ADC图还显示出高强度，这意味着T2高信号代表T2发光，这可能是由于水肿变化所致。 T2和扩散加权图像和临床症状与血清肌酸激酶的高信号之间存在相关性。肌发育症的原因是染色体19染色体上的Q13.3的CTG（胞嘧啶 - 胸甲氨酸 - 瓜氨酸）的过度扩张。三重态扩展的数量与MR T2高信号无关。另一方面，肌肉营养不良的患者对腿部静脉血栓形成具有很高的风险。这项研究还证明了MR上扩散加权图像的优点。在扩散加权图像上显示急性血栓形成为明亮信号，而在ADC图上显示低或等值效率。在没有造影剂的情况下检测血栓形成有时会引起副作用是有用的。

项目成果

Hemimegalencephaly: astudy of abnormalities occurring outside ofthe involved hemisphere

半侧巨脑畸形：对相关半球外部发生的异常的研究

• 发表时间: 2007
• 期刊: AJNR Am J Neuroradiol 28(4)
• 作者: Sato N;Yagishita A;Oba H;et. al.
• 通讯作者: et. al.

Magnetic resonance imaging in congenital facial palsy.

先天性面瘫的磁共振成像。

• 发表时间: 2007
• 期刊: Brain Dev. (Epub ahead of print)
• 作者: Sasaki M;Imamura Y;Sato N.
• 通讯作者: Sato N.

Relatiohship between diffusion tensor imaging and brain morphology in patients with myotonic dystiophy.

强直性肌营养不良患者弥散张量成像与脑形态之间的关系。

• 发表时间: 2006
• 期刊: Neuroscience Letters 407
• 作者: Ota M;Sato N;Ohya Y;Aoki Y;Mizukami K;Mori T;Asada T.
• 通讯作者: Asada T.

MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images:it is useful for differentiation from medulloblastoma?

T2加权图像上毛细胞星形细胞瘤实性部分的MR信号：有助于与髓母细胞瘤鉴别吗？

• 发表时间: 2006
• 期刊: Neuroradiology 48
• 作者: Arai K;Sato N;et. al.
• 通讯作者: et. al.

造影3DCISSMR画像における海綿静脈洞内の正常と病理の脳神経の評価

在对比增强 3D ISSMR 图像中评估海绵窦内的正常和病理性颅神经

• 发表时间: 2006
• 作者: 佐藤典子、八木明子;他
• 通讯作者: 他