High resolutional MR images of cochlear nerves and functional PET of temporal lobes in patients with sensory nerve hearing loss.

感觉神经性听力损失患者耳蜗神经的高分辨率 MR 图像和颞叶的功能 PET。

• 批准号: 14570837
• 负责人: SATO Noriko
• 金额: $ 1.34万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570837/
• 关键词: kannouseinanncyou; cochlear nerve; MR; CISS; Positron CT

The new MR sequence, CISS (constructive interference with steady state), provide high resolutional images which had not been imaged before. Cochlear nerve that is responsible for auditory system can be demonstrated by MR CISS images. We examined the anatomical abnormalities of cochlear nerve in patients with auditory disturbance using MR CISS images. We examined whether there is any differences of cochlear nerve size among various diseases or between before and after treatment. At the same time, brain blood volume was also estimated on positron CT by auditory stimulations before and after treatment and examined the differences of brain blood volume between two patients' groups of improvement and non-respons by treatment.Patients with unilateral sensory neural hearing loss without neoplasms such as acoustic shwanoma were selected. High-resolutional 3D images were scanned with MR CISS sequences (effective slice thickness was 0.7mm), and cranial nerve 7th and 8th were reconstructed vertic … More al to the nerves. The size of cochlear nerve on reconstructed images was compared of right and left. In patients who was infetected by mumpus virus, the size of cochlear nerve at disease side was smaller then the contralateral side. But facial and vestibular nerves were symmetric. On the other hand, in patients with idiopathic hearing loss, which are supposed to be caused by blood flow disturbance, there were no differences of both sides.Pure sound stimulation test was examined in patients with idiopathic auditory disturbance on positron CT. The treatment was steroid and high oxygen therapy. In patients who were improved after treatment, bilateral temporal blood volume were increased compared to that before treatment. There were no blood volume differences between before and after treatment in patients who did not respond by the therapy.It is clinical asset to demonstrate anatomical and functional abnormalities that had not been detected before. We evaluate the morphological change objectively and this method is helpful to precise diagnose in patients with auditory disturbance. Less

新的 MR 序列 CISS（稳态相长干涉）可提供以前从未成像过的高分辨率图像。负责听觉系统的耳蜗神经可以通过 MR CISS 图像来展示。我们使用 MR CISS 图像检查了听觉障碍患者耳蜗神经的解剖异常。我们检查了不同疾病之间或治疗前后的耳蜗神经大小是否存在差异。同时，在治疗前后通过听觉刺激在正电子CT上评估脑血容量，并检查治疗改善和无反应两组患者脑血容量的差异。 选择无声神经鞘瘤等肿瘤的单侧感觉神经性听力损失患者。使用 MR CISS 序列扫描高分辨率 3D 图像（有效切片厚度为 0.7mm），重建第 7 和第 8 脑神经的垂直顶点。比较左右重建图像上耳蜗神经的大小。感染腮腺炎病毒的患者，病侧耳蜗神经的尺寸小于对侧。但面部神经和前庭神经是对称的。另一方面，在被认为是由血流障碍引起的特发性听力损失患者中，两侧没有差异。对特发性听力障碍患者进行正电子CT检查纯声刺激试验。治疗方法是类固醇和高氧疗法。治疗后好转的患者，双侧颞部血容量较治疗前有所增加。对治疗无反应的患者在治疗前后没有血容量差异。证明以前未检测到的解剖和功能异常是临床资产。我们客观地评估形态学变化，该方法有助于听觉障碍患者的精确诊断。较少的

项目成果

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