MORPHOLOGICAL AND FUNCTIONAL REGENERATION OF THE CIRRHOTIC LIVER -THE EFFECT OF PARTIAL HEPATECTOMY IN THE RAT

肝硬化肝的形态和功能再生-部分肝切除对大鼠的影响

• 批准号: 12671288
• 负责人: HASHIMOTO Masaji
• 金额: $ 2.24万
• 依托单位: OKINAKA MEMORIAL INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671288/
• 关键词: liver cirhosis; partial hepatectomy; functional capacity; funtionai regeneration; morphological regeneration; indocyanine green; aminopyyrine; antipyrine; アミノビリン

BACKGROUND: Although cirrhosis is the terminal stage of various liver diseases, thanks to recent advances one might eliminate some causes of liver damage. Liver has a potent regeneration capacity. It is important to evaluate the regenerating cirrhotic liver after partial hepatectomy, morphologically and functionally, during a long term.STUDY DESIGN: We evaluated the functional capacity of the rat liver rendered cirrhotic by orally administered thioacetamide, and examined the correlation between morphological and functional restoration after 2/3 hepatectomy in comparison with hepatectomized normal rats and sham-operated cirrhotic rats. Morphological restoration was evaluated by remnant liver weight, proliferating cell nuclear antigen labeling index, and fibrosis ratio. Functional restoration was evaluated by the indocyanine green disappearance rate and aminopyrine clearance.RESULTS: Cirrhotic rats were functionally deteriorated in comparison with the normal rats. Morphological restoration in cirrhotic rats was delayed in comparison with normal rats. Functional restoration after 2/3 hepatectomy was advanced in comparison with morphological restoration. In comparison with sham-operated cirrhotic rats, functional restoration of the cirrhotic liver was accelerated by partial hepatectomy.CONCLUSIONS: In cirrhotic rats, functional restoration of the liver after 2/3 hepatectomy was advanced in comparison with morphological restoration. Partial hepatectomy seemed to promote functional restoration of the cirrhotic liver.

背景：虽然肝硬化是各种肝脏疾病的终末期，但由于最近的进展，人们可能会消除一些肝脏损害的原因。肝脏有强大的再生能力。对肝部分切除术后肝硬化再生肝的形态学和功能进行长期评估是很重要的。研究设计：我们评估口服硫乙酰胺导致肝硬化的大鼠肝脏的功能能力，并与正常大鼠和假手术的肝硬化大鼠进行比较，检查2/3肝切除术后肝脏形态和功能恢复之间的相关性。以残肝重、增殖细胞核抗原标记指数、纤维化率评价形态学恢复情况。以吲哚菁绿消失率和氨基吡啶清除率评价功能恢复情况。结果：肝硬化大鼠与正常大鼠相比，肝功能明显恶化。肝硬化大鼠的形态恢复较正常大鼠延迟。2/3肝切除术后功能恢复较形态学恢复更早。与假手术的肝硬化大鼠相比，部分肝切除术加速了肝硬化肝脏的功能恢复。结论：在肝硬化大鼠中，与形态恢复相比，2/3肝切除术后肝脏功能恢复提前。肝部分切除术似乎能促进肝硬化的功能恢复。

项目成果

Masaji Hashimoto, et al.: "Intraductal papillary-mucinous cystadenocarcinoma of the pancreas"Pancreas. 24(3). 313-314 (2002)

Masaji Hashimoto 等人：“胰腺导管内乳头状粘液性囊腺癌”胰腺。

橋本雅司,三辺大介,松田正道,渡辺五朗: "急性胆嚢炎"外科. 62(12). 1549-1552 (2000)

Masashi Hashimoto、Daisuke Sanbe、Masamichi Matsuda、Goro Watanabe：“急性胆囊炎”手术 62(12) (2000)。

橋本雅司: "腹部エコー 基本走査と典型症例,ポリープ型胆嚢癌"日経BP社. 151 (2000)

Masashi Hashimoto：“基础腹部超声扫描和典型病例，息肉样胆囊癌”Nikkei BP 151（2000）。

Masaji Hashimoto, et al.: "Right hepatic duct. emptying into cystic duct."Surgical Endoscopy. 16(2). 359-359 (2002)

Masaji Hashimoto 等人：“右肝管。排空至胆囊管。”外科内窥镜检查。

Masaji Hashimoto, et al.: "Reduction of the risk of unretrieval stones during laparoscopic cholecystectomy"Hepatogastroenterdogy. 50. 325-328 (2003)

Masaji Hashimoto 等人：“降低腹腔镜胆囊切除术期间未取出结石的风险”肝胃肠病学。