Effect of semaphorin on sinusoidal remodeling : the role in liver regeneration after partial hepatectomy

本研究旨在阐明轴突引导因子信号素3A(Sema3A)及其受体神经粘连蛋白-1(NRP-1)在肝再生过程中肝窦重构中的作用。在体内，肝窦内皮细胞(SECs)的NRP-1表达增加，而肝细胞Sema3A的表达降低。在体外实验中，Sema3A显著抑制大鼠肝部分切除后SEC的迁移和诱导细胞凋亡。总之，我们的研究结果显示，Sema3A和NRP-1的相互作用可能有助于更好地理解肝再生过程中的肝窦重构。

The study was investigated to elucidate the role of semaphorin 3A(Sema3A), an axon guidance factor, and its receptor, neuropilin-1(Nrp-1), in sinusoidal remodeling during liver regeneration. In vivo, Nrp-1 expression in sinusoidal endothelial cells(SECs) was increased, while Sema3A expression in hepatocytes was decreased after two-thirds partial hepatectomy(PHx). In vitro study, Sema3A significantly attenuated migration and induced apoptosis in SECs isolated from rats after partial hepatectomy(PHx-SECs). In conclusion, the interplay of Sema3A and Nrp-1 shown in our results may lead to a better understanding of sinusoidal remodeling during liver regeneration.