The role of Tumor Necrosis factor in radicular pain

肿瘤坏死因子在神经根痛中的作用

• 批准号: 12671431
• 负责人: YABUKI Shoji
• 金额: $ 1.41万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671431/
• 关键词: tumor necrosis factor; radicular pain; disc herniation; compartment syndrome

It has been shown using herniated nucleus pulposus model that application of pentoxifylline, an anti-TNF drug, with nucleus pulposus can prevent the increase of endoneurial fluid pressure (EFP) in the rat dorsal root ganglia (DRG) in 2000.The purpose of the study in 2001 is to clarify whether application of TNF to the nerve root induces abnormal discharges in rat dorsal horn neurons or not, and to clarify the effects of lidocaine which used in nerve root block for treating the radicular pain on the increase of EFP and edema formation in the DRG in the herniated nucleus pulposus model.The results were following; 1) TNF induced abnormal discharges in rat dorsal horn neurons, and 2) lidocaine prevented the increase of EFP and edema formation in the DRG in the herniated nucleus pulposus model. The result 1) suggests that TNF plays an important role to induce radicular pain. Also, the result 2) may show a mechanism of the therapeutic effect nerve root block.In the 2001 studies, it is shown that TNF plays an important role to induce radicular pain, and nerve root block is an useful method for treating the radicular pain.

2000年在大鼠髓核突出模型上发现，髓核内应用抗肿瘤坏死因子（TNF）药物喷替福林（pentaphylline）可防止大鼠背根神经节（DRG）神经内液压力（EFP）的升高。2001年的研究目的是阐明神经根内应用TNF是否引起大鼠背角神经元异常放电，观察利多卡因神经根阻滞治疗根性疼痛对髓核突出模型DRG内EFP增加和水肿形成的影响。1）TNF诱导大鼠脊髓背角神经元异常放电，2）利多卡因可防止髓核突出模型DRG内EFP的增加和水肿的形成。结果提示TNF在神经根痛的发生中起重要作用。2001年的研究表明，TNF在诱发神经根性疼痛中起重要作用，神经根阻滞是治疗神经根性疼痛的有效方法。

项目成果

Akira Onda: "Exogenous tumor necrosis factor induces abnormal discharges in rat dorsal horn neurons"Spine. 27(accepted). (2002)

Akira Onda：“外源性肿瘤坏死因子诱导大鼠背角神经元异常放电”脊柱。

Shoji YABUKI: "Prevention of compartment syndrome in dorsal root ganglia caused by exposure to nucleus pulposus"Spine. 26. 870-874 (2001)

Shoji YABUKI：“预防因暴露髓核而引起的背根神经节筋膜室综合征”脊柱。

Onda A, Yabuki S, Kikuchi S, Satoh K, Myers RR: "Effects of lidocaine on blood flow and endoneurial fluid pressure in a rat model of herniated nucleus pulposus"Spine 26. 2186-2192 (2001)

Onda A、Yabuki S、Kikuchi S、Satoh K、Myers RR：“利多卡因对髓核突出大鼠模型血流和神经内液压力的影响”Spine 26. 2186-2192 (2001)

Igarashi T, Kikuchi S, Shubayeb V, Myers RR: "Exgenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology"Spine 25. 2975-2980 (2000)

Igarashi T、Kikuchi S、Shubayeb V、Myers RR：“外源性肿瘤坏死因子-α 模拟髓核诱发的神经病理学”Spine 25. 2975-2980 (2000)

Onda A, Hanaba M, Yabuki S, Kikuchi S: "Exogenous tumor necrosis factor induces abnormal discharges in rat dorsal horn neurons"Spine. (accepted).

Onda A、Hanaba M、Yabuki S、Kikuchi S：“外源性肿瘤坏死因子诱导大鼠背角神经元异常放电”脊柱。