ESTABLISHMENT OF MEASUREMENTS METHOD FOR COMPACT BONE MINERAL DENSITY BY HELICAL SCAN CT WITH HA-C REFERENCE

以HA-C为参考的螺旋扫描CT致密骨密度测量方法的建立

• 批准号: 12671791
• 负责人: SHIMODA Shinji
• 金额: $ 2.37万
• 依托单位: TSURUMI UNIVERSITY, SCHOOL OF DENTAL MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671791/
• 关键词: QCT; COMPACT BONE; REFERENCE FOR BMD; OSTEOPOROSIS; CT; HYDROXYAPATITE; BMD; H.U. UNIT; 骨塩量用ファントーム; 骨塩基; 参照体; 診断法; CT

The main purpose of this prefect, i.e. establishment of measurements method for compact bone mineral density by helical scan CT with HA-C reference were completed. The features of this new reference were as furrows ; (1) The materials of new reference is consist of hydroxyapatite and pure carbon. (2) The CT number of 100% references have higher than compact bone. (3) The accuracy were verified by the examination using human cadavers.The new columnar shape references, 3.4 - 5.7 mm in height and 1 3.05 + 0.10 m diameter, consists of two materials : hydroxyapatite (HA) which was prepared in our laboratory according to the Shimoda (1990) method, and 99.9% carbon(C) : (Soekawa Chemicals Tokyo). After using an agate mortar and pestle to make a mixture of fine granules of hydroxyapatite and carbon powder using at the exact weight ratios of 100, 80, 60, 40, 20%, each mixed sample was pressed using a metal mold and presser (shimazu, at 600kg/cm2) equipped with a vacuum pump. These five step HA- … More C pellets were used as a CT standard after measuring their accurate weight and volume. The unit of references, therefore, represented HA weight (mg) per unit volume (mm) according to the hydroxyapatite contents of each pellet. The spiral CT images were taken as a test measurement of CT value using a human cadaver equipped with the references at the menton region of mandible. The CT images were taken under the following conditions : slice thickness 1 mm table forward speed, 1mm/sec : X-ray tube voltage, 120kV tube current ranges between 75 - 175mA. The CT values of the references were in a range between 2583.1±25.28〜351.91±17.66, and the CT value to HA mg/mm of each reference showed positive linear regression (r= 0.9996). The maximum CT value of the compact bone in the mandible was 1665.9±198.43, and the conversion value in HA weights per unit volume was 1.393mg/mm3. After the test measurements of the CT value of the new references in regard to human com-pact bone the validity of the references was examined by biopsy using human cadaver.The clinical test measuring of BMD in age twenties to sixties woman showed that the maximum BMD values of compact bone in human mandible were seen at thirties and then decreased with ageing. It is considered that more extensive studies should be done quickly. Less

本次会议的主要目的，即以HA-C为参考的螺旋扫描CT密实骨密度测量方法的建立已经完成。这个新参考的特征是犁沟； (1)新参考材料由羟基磷灰石和纯碳组成。 (2)100%参考的CT值高于致密骨。 (3) The accuracy were verified by the examination using human cadavers.The new columnar shape references, 3.4 - 5.7 mm in height and 1 3.05 + 0.10 m diameter, consists of two materials : hydroxyapatite (HA) which was prepared in our laboratory according to the Shimoda (1990) method, and 99.9% carbon(C) : (Soekawa Chemicals Tokyo). After using an agate mortar and pestle to make a mixture of fine granules of hydroxyapatite and carbon powder using at the exact weight ratios of 100, 80, 60, 40, 20%, each mixed sample was pressed using a metal mold and presser (shimazu, at 600kg/cm2) equipped with a vacuum pump.在测量准确的重量和体积后，将这五步 HA-… 更多 C 颗粒用作 CT 标准品。因此，参考单位代表根据每个颗粒的羟基磷灰石含量每单位体积（mm）的HA重量（mg）。使用配备有下颌骨芒通区参考的人体尸体拍摄螺旋CT图像作为CT值的测试测量。 The CT images were taken under the following conditions : slice thickness 1 mm table forward speed, 1mm/sec : X-ray tube voltage, 120kV tube current ranges between 75 - 175mA.各参考文献的CT值范围为2583.1±25.28〜351.91±17.66，各参考文献的CT值对HA mg/mm呈正线性回归（r=0.9996）。 The maximum CT value of the compact bone in the mandible was 1665.9±198.43, and the conversion value in HA weights per unit volume was 1.393mg/mm3. After the test measurements of the CT value of the new references in regard to human com-pact bone the validity of the references was examined by biopsy using human cadaver.The clinical test measuring of BMD in age twenties to sixties woman showed that the maximum BMD values of compact bone in human mandible were seen at thirties and then decreased with ageing.人们认为应该尽快进行更广泛的研究。较少的

项目成果

下田信治, 川原英明, 川崎堅三, 他: "緻密骨の骨密度の測定"Acta Anatomica Nipponica. 75(1). 72 (2000)

Shinji Shimoda、Hideaki Kawahara、Kenzo Kawasaki 等人：“致密骨骨密度的测量”Acta Anatomica Nipponica 75(1) (2000)。

Kaoru Kobayashi, Shinji Shimoda, Masao Yuasa, et al: "3D images in Teomporo-mandibular joint -The present and the future- (Japanese)"Dental Outlook. 98. 826-831 (2001)

Kaoru Kobayashi、Shinji Shimoda、Masao Yuasa 等人：“Teomporo-下颌关节的 3D 图像 - 现在和未来 -（日语）”牙科展望。

S.Shimoda, K.Kobayashi, and A. Yamamoto: "Assessment of limited cone beam CT for the preoperative examination of dental implant"Proceedings of 5^<th> World Congress for Oral Implantology - biomechanics and Tissue Engineering-. Special edition. 146-147 (20

S.Shimoda、K.Kobayashi 和 A. Yamamoto：“牙种植术前检查的有限锥形束 CT 评估”第 5 届世界口腔种植大会论文集 - 生物力学和组织工程 -。

小林 馨: "顎関節領域の三次元画像表示の現状と未来"歯界展望. 98・4. 826-831 (2001)

小林薰：“颞下颌关节区域的三维图像显示的现状和未来”Dental Perspective 98・4（2001）。

小林 馨, 柳澤慧二: "鶴見大学歯学部顎機能センター(ハイテク・リサーチセンター)第2の概要について"鶴見歯学. 26(3). 353-359 (2000)

Kaoru Kobayashi、Keiji Yanagisawa：“鹤见大学牙科学院第二颌功能中心（高科技研究中心）概述”Tsurumi Dentistry 26（3）（2000）。