Biological Activities of Triterpene Saponins Mediated by Stimulating on Nervous System in Digestive Tract

三萜皂苷通过刺激消化道神经系统介导的生物活性

• 批准号: 12672075
• 负责人: YOSHIKAWA Masayuki
• 金额: $ 2.43万
• 依托单位: Kyoto Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12672075/
• 关键词: Aesculus hippocastanum; Trigonella foenum-graceum; Euptelea polyandra; Camellia sinensis var. assamica; Pisum sativum; Momordica charantia; triterpene saponin; digestive tract; サポニン; 神経伝達物質; エンドウ; 田七人参; 血糖値上昇抑制

Oleanolic acid (ex. momordine Ic) and acylated polyhydroxyolean-12-ene 3-monodesmosides (ex. escins) were found to have neither insulin-like nor insulin-releasing activity, but they inhibited gastric emptying and glucose-uptake in the small intestine. Investigation of the mode of action revealed that the inhibition of gastric emptying was mediated by capsaicin-sensitive sensory nerves and the stimulating the release and/or production of dopamine to act through dopamine, receptors, which in turn causes of prostaglandins.

齐墩果酸（例如苦瓜碱 Ic）和酰化多羟基齐墩果酸 12-烯 3-单链苷（例如七叶皂苷）被发现既不具有胰岛素样活性也不具有胰岛素释放活性，但它们抑制胃排空和小肠中的葡萄糖摄取。对作用方式的研究表明，胃排空的抑制是由辣椒素敏感的感觉神经介导的，并通过多巴胺受体刺激多巴胺的释放和/或产生，从而产生前列腺素。

项目成果

Masayuki Yoshikawa: "Antidiabetogenic Activity of Oleanolic Acid Glycosides from Medicinal Foodstuffs"Bio Factors. 13. 231-237 (2000)

Masayuki Yoshikawa：“药用食品中齐墩果酸苷的抗糖尿病活性”生物因素。

Masayuki Yoshikawa: "Bioactive Saponins and Glycosides. XVI. Nortriterpene Oligoglycosides with Gastroprotective Activity from the Fresh Leaves of Euptelea polyandra SIEB.et Zucc.(I):Structures of Eupteleasaponins I, II, III, IV, V, and V Acetate"Chem.Pha

Masayuki Yoshikawa：“生物活性皂苷和糖苷。XVI.来自 Euptelea Polyandra SIEB.et Zucc 新鲜叶的具有胃保护活性的去甲三萜寡糖苷。(I)：Eupteleasaponins I、II、III、IV、V 和 V 乙酸酯的结构”化学

Toshiyuki Murakami: "Bioactive Saponins and Glycosides. XVII. Inhibitory Effect on Gastric Emptying and Accelerating Effect on Gastrointestinal Transit of Tea Saponins : Structures of Assamsaponins F, G, H, I, and J from the Seeds and Leaves of the Tea Pl

Toshiyuki Murakami：“生物活性皂苷和糖苷。XVII.茶皂苷对胃排空的抑制作用和对胃肠道转运的加速作用：来自茶树种子和叶子的阿参皂苷 F、G、H、I 和 J 的结构

Masayuki Yoshikawa el al.: "Bioactive Saponins and Glycosides. XVI. Nortriterpene Oligoglycosides with Gastroprotective Activity from the Fresh Leaves of Euplelea polyandra SIEB. et ZUCC. (1): Structures of Eupteleasaponins I, II, III. IV, V, and V Acetat

Masayuki Yoshikawa 等人：“生物活性皂苷和糖苷。XVI。来自 Euplelea Polyandra 新鲜叶的具有胃保护活性的去甲三萜寡糖苷 SIEB。等 ZUCC。(1)：Eupteleasaponins I、II、III 的结构。IV、V 和 V

Hisashi Matsuda el al.: "Possible Involvement of 5-HT_2 Receptors in Acceleration of Gastrointestinal Transit by Escin Ib in Mice"Life Sci.. 66. 2233-2238 (2000)

Hisashi Matsuda 等人：“小鼠中七叶皂苷 Ib 可能参与 5-HT_2 受体加速胃肠转运”Life Sci.. 66. 2233-2238 (2000)