Search for Bioactive Compounds on the Basis of Characterization of Crude Drug Processings

基于生药加工表征寻找生物活性化合物

基本信息

  • 批准号:
    08672461
  • 负责人:
  • 金额:
    $ 1.22万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1996
  • 资助国家:
    日本
  • 起止时间:
    1996 至 1997
  • 项目状态:
    已结题

项目摘要

In traditional Chinese medicine, crude drugs (naturally occurring drug materials) are often used after appropriate processings. The procedure of processing for individual crud drug has been devised in the progress of Chinese medicine, and it has been conveyed nowadays as the conventional and traditional technique. By means of chemical comparisons in detail of the constituents in those crude drugs before and after processings, it has been anticipated to discover new biologically active substances. During the course of these chemical characterization studies of crude processings, we have investigated ginger (Zingiberis Rhizoma), saussurea root (Saussureae Radix), sweet hedrangea leaf (Hydrangeae Dulcis Folium), jujuba seed (Zizyphi Spinosi Semen), peony root (Paeoniae Radix), and notoginseng root (Sanchi ginseng). On the basis of detailed characterization of their chemical and pharmacological differences between the unprocessed and processed natural medicines, various chemically then new and biologically interesting compounds were isolated from those processed natural medicines.
在传统中药中,原料药(天然药物材料)通常经过适当的加工后使用。中药饮片的炮制工艺是在中医药发展过程中形成的,目前已作为传统中药饮片的炮制工艺进行推广。通过对炮制前后的生药成分进行详细的化学比较,有望发现新的生物活性物质。在这些粗加工的化学表征研究过程中,我们研究了生姜(生姜)、风毛菊根(雪莲根)、甜绣球叶(绣球花)、酸枣仁(酸枣仁)、牡丹根(芍药根)和三七根(三七)。在详细描述天然药物的化学和药理学差异的基础上,从天然药物中分离出各种化学上新的和生物学上有趣的化合物。

项目成果

期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Masayuki Yoshikawa: "New Bioactive Monoterpene Glycosides from Paeoniae Radix" Chemical & Pharmaceutical Bulletin. 44・6. 1279-1281 (1996)
Masayuki Yoshikawa:“来自芍药的新生物活性单萜苷”化学与制药通报44・6(1996)。
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    0
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Masayuki Yoshikawa, Hiromi Shimada, Nobuhiro Yagi, Nobutoshi Murakami, Hiroshi Shimoda, Johji Yamahara, and Hisashi Matsuda: "Development of Bioactive Functions in Hydrangeae Dulcis Folium. VI.Syntheses of Thunberginols A and F and Their 3'-Deoxy-derivati
Masayuki Yoshikawa、Hiromi Shimada、Nobuhiro Yagi、Nobutoshi Murakami、Hiroshi Shimoda、Johji Yamahara 和 Hisashi Matsuda:“绣球花生物活性功能的开发。VI. 桑姜醇 A 和 F 及其 3-脱氧衍生物的合成
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    0
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Masayuki Yoshikawa: "Bioactive Saponins and Glycosides.VIII.Notoginseng(1):New Dammarane-Type Triterpene Oligoglycosides,Notoginsenosides -A,-B,-C,and -D,from the Dried Root of Panax notoginseng(BURK.)F.H.CHEN." Chemical & Pharmaceutical Bulletin. 45・6. 1
Masayuki Yoshikawa:“生物活性皂苷和苷。VIII.三七(1):新达玛烷型三萜寡糖苷,三七皂苷-A、-B、-C和-D,来自三七干根(BURK.)F.H.CHEN .” 化学药品通报. 45・6. 1
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    0
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Masayuki Yoshikawa: "New Bioacive Monoterpene Glycosides from Paeoniae Radix.." Chemical & Pharmaceutical Bulletin. 44. 1279-1281 (1996)
Masayuki Yoshikawa:“来自芍药的新生物活性单萜苷..”化学
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    0
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Masayuki Yoshikawa: "Bioactive Saponins and Glycosides.X.On the Constituents of Zizyphi Spinosi Semen,the Seeds of Zizyphus jujuba MILL.var.spinosa HU(1):Structures and Histamine Release-Inhibitory Effect of Jujubosides Al and C and Acetyljujuboside B." C
Masayuki Yoshikawa:“生物活性皂苷和糖苷。X.关于酸枣仁、酸枣种子的成分 HU(1):酸枣苷 Al 和 C 以及乙酰酸枣苷 B 的结构和组胺释放抑制作用。
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YOSHIKAWA Masayuki其他文献

Localized Density Fluctuation in the Downstream of Detached Plasma
分离等离子体下游的局部密度波动
  • DOI:
    10.1585/pfr.12.1202007
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0.8
  • 作者:
    TAKEYAMA Kohei;OHNO Noriyasu;YOSHIKAWA Masayuki;TANAKA Hirohiko;KAJITA Shin
  • 通讯作者:
    KAJITA Shin
Influence of Nitrogen Ratio on Plasma Detachment during Combined Seeding with Hydrogen on Divertor Simulation Experiment of GAMMA 10/PDX
GAMMA 10/PDX 偏滤器模拟实验中氢混播过程中氮配比对等离子体脱离的影响
  • DOI:
    10.1585/pfr.16.2402041
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0.8
  • 作者:
    GAMO Hiroki;EZUMI Naomichi;SUGIYAMA Tsukasa;NOJIRI Kunpei;KONDO Ayane;HIRATA Mafumi;KOHAGURA Junko;YOSHIKAWA Masayuki;NAKASHIMA Yousuke;HWANGBO Dogyun;SAKAMOTO Mizuki;PERILLO Renato;KUWABARA Tatsuya;TANAKA Hirohiko;OHNO Noriyasu;SAWADA Keiji;TONEGAWA Akir
  • 通讯作者:
    TONEGAWA Akir
Development of a Fast Visible Light Measurement System for the Study of Ion Cyclotron Range of Frequency Waves in GAMMA 10/PDX Plasmas
开发用于研究 GAMMA 10/PDX 等离子体中离子回旋频率波范围的快速可见光测量系统
  • DOI:
    10.1585/pfr.16.1402096
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0.8
  • 作者:
    EJIRI Akira;HIRATA Mafumi;ICHIMURA Makoto;YOSHIKAWA Masayuki;IKEZOE Ryuya;KAMIO Shuji
  • 通讯作者:
    KAMIO Shuji
Effects from the Target Plate Geometry on Fluctuations of Helium Plasma in the Linear Divertor Simulator Magnum-PSI
线性偏滤器模拟器 Magnum-PSI 中靶板几何形状对氦等离子体波动的影响
  • DOI:
    10.1585/pfr.17.1402100
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0.8
  • 作者:
    YOSHIKAWA Masayuki;TANAKA Hirohiko;HAYASHI Yuki;KAJITA Shin;van der MEIDEN Hennie;VERNIMMEN Jordy;MORGAN Thomas;KOHAGURA Junko;SHIMA Yoriko;TOGO Satoshi;EZUMI Naomichi;NAKASHIMA Yousuke;SAKAMOTO Mizuki
  • 通讯作者:
    SAKAMOTO Mizuki
イオン源プラズマの原子・分子過程
离子源等离子体中的原子和分子过程
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    GAMO Hiroki;EZUMI Naomichi;SUGIYAMA Tsukasa;NOJIRI Kunpei;KONDO Ayane;HIRATA Mafumi;KOHAGURA Junko;YOSHIKAWA Masayuki;NAKASHIMA Yousuke;HWANGBO Dogyun;SAKAMOTO Mizuki;PERILLO Renato;KUWABARA Tatsuya;TANAKA Hirohiko;OHNO Noriyasu;SAWADA Keiji;TONEGAWA Akir;柴田崇統,澤田圭司
  • 通讯作者:
    柴田崇統,澤田圭司

YOSHIKAWA Masayuki的其他文献

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{{ truncateString('YOSHIKAWA Masayuki', 18)}}的其他基金

A classification study of Unique Forms and Usages of Chinese Characters
汉字形体及用法的分类研究
  • 批准号:
    25284076
  • 财政年份:
    2013
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Search for protective compounds from Egyptian traditional medicines on metabolic syndrome
从埃及传统药物中寻找对代谢综合征的保护性化合物
  • 批准号:
    21590031
  • 财政年份:
    2009
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A general study on the unclassified languages spoken in the southern Hunan province of China
湘南地区未分类语言概况
  • 批准号:
    20401020
  • 财政年份:
    2008
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development for preventive and therapeutic constituents on lifestyle diseases from spices
从香料中开发预防和治疗生活方式疾病的成分
  • 批准号:
    19590024
  • 财政年份:
    2007
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SEARCH FOR NEW ANTIDIABETOGENIC AND ANTI-OBESE SEED COMPOUNDS FROM THE TRADITIONAL EGYPTIAN MEDICINES
从传统埃及药物中寻找新的抗糖尿病和抗肥胖种子化合物
  • 批准号:
    16590023
  • 财政年份:
    2004
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A Sociolinguistic Study on the Transition and Variation of Reading and Writing in Hong Kong.
香港阅读和写作的转变和变异的社会语言学研究。
  • 批准号:
    16320048
  • 财政年份:
    2004
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
SEARCH FOR ANTI-OBESE AND ANTIDIABETOGENIC PRINCIPLES FROM THE AYURUVEDIC NATURAL MEDICINES
从阿育吠陀天然药物中寻找抗肥胖和抗糖尿病原理
  • 批准号:
    14572022
  • 财政年份:
    2002
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Biological Activities of Triterpene Saponins Mediated by Stimulating on Nervous System in Digestive Tract
三萜皂苷通过刺激消化道神经系统介导的生物活性
  • 批准号:
    12672075
  • 财政年份:
    2000
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Characterization of Hepatoprotective Compounds from Chinese Medicinal Herbs with Anti-alcoholic Activity
具有抗酒精活性的中药保肝化合物的表征
  • 批准号:
    10672010
  • 财政年份:
    1998
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Characterization of Alcohol-Absorption Inhibitors from Chinese Traditional Medicines with Anti-Alcoholic Activity
具有抗酒精活性的中药酒精吸收抑制剂的表征
  • 批准号:
    07557292
  • 财政年份:
    1995
  • 资助金额:
    $ 1.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

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亚洲传统医学的医学伦理、行医规则及其思想渊源研究
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    19H00515
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    15K21371
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The effect of traditional medicine on busulfan- and/or irradiation-induced aspermatogenesis
传统医学对白消安和/或辐射诱导的精子发生的影响
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