The study for a visible technique of blood vessel elasticity by analyses from information of multiple dimensions and spatio temporal image

多维度信息和时空图像分析血管弹性可视化技术研究

• 批准号: 12680853
• 负责人: NAGAKURA Toshiaki
• 金额: $ 2.3万
• 依托单位: Department of Biomedical Engineering Faculty of Engineering Osaka Electro-Communication University (2002)Suzuka University of Medical Science (2000-2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680853/
• 关键词: Functional tissue characterization; Arteriosclerosis; Index; IMT; β; Multiple dimensions; 3D mode image; 4D mode image; 4Dモード

It is for a purpose of this study to check in a non-invasive an arteriosclerosis before the morphologic change which I cannot detect in a conventional diagnostic method. We call this method a functional tissue characterization. By high speed ultrasound echography, we measure a change of cross-section area of a carotid artery, expansion speed in a resolution by a less wavelength of the ultrasound.The measured continuous blood pressure in a tonometry method on an echo image simultaneously recorded. Analyzed how carotid artery transformed by blood pressure, it would be the diagnosis for arteriosclerosis, in other words it would be a non-invasive arteriosclerosis diagnosis system. From a change of this being viscoelasitc studies, we showed that functional behavior of an artery wall of a young was different from a senior. Furthermore, we developed 3D mode image which arranged time series of the carotid artery cross section which displayed the action of cross section of carotid artery. Furth … More ermore, we did development to the 4D mode image which displayed intuitively existence of an arteriosclerosis a color mapping of blood pressure information on the 3D mode image. By this method, it is possible to understand visually localizing arteriosclerosis more easily.We examined comparison between our index and IMT (the thickness of a membrane complex of carotid artery wall) which is common index of arteriosclerosis, a and β index and which is standard index from a standpoint of elastic studies. From the result, as for all indexes, as for the index, increase tends by an aging, but there is a case to slip off in a senior greatly in β. IMT used commonly for evaluation of an arteriosclerosis is the superior index which is stable in a quantitative diagnosis of an arteriosclerosis currently. However, existence of an arteriosclerosis can be estimated, but it is only an average index of an arteriosclerosis. The greatest problems, it can not detect arteriosclerosis, If an arteriosclerosis does not progress, So it in not a sensitive to an arteriosclerosis in a young. However, our method can diagnose even young. Furthermore, our method have a visual and quantitative evaluation, it is possible to estimate, even if an arteriosclerosis is not average type. This method may be effective in n arteriosclerosis diagnosis for the artery does not have an morphologic change. Less

这项研究的目的是在常规诊断方法中无法检测到的形态变化之前检查非侵袭性动脉硬化。我们称这种方法为功能性组织定征。利用高速超声测量颈动脉横截面积的变化，以较小的超声波长在分辨率上测量扩张速度，用眼压计的方法在回波图像上同时记录连续测得的血压。分析颈动脉是如何通过血压变化的，它将是对动脉硬化的诊断，换句话说，它将是一种无创的动脉硬化诊断系统。从粘弹性研究的变化来看，我们发现年轻人的动脉壁功能行为与老年人不同。此外，我们还开发了三维模式图像，排列了颈动脉横截面的时间序列，显示了颈动脉横截面的作用。更进一步的…此外，我们还对直观显示动脉硬化存在的4D模式图像进行了开发，将血压信息的彩色映射到3D模式图像上。通过这种方法，可以更容易地直观地了解动脉硬化的局限性。我们从弹性研究的角度考察了我们的指数与颈动脉壁膜复合体厚度(IMT)的比较，IMT是动脉硬化的常见指标，a和β指数是标准指标。从结果来看，对于所有的指数来说，对于指数来说，随着年龄的增长，指数都有上升的趋势，但在β中有一个较大幅度下滑的情况。IMT常用于评价动脉硬化，是目前动脉硬化定量诊断中较为稳定的一项优越指标。然而，动脉硬化的存在是可以估计的，但它只是动脉硬化的一个平均指标。最大的问题是，它不能检测到动脉硬化，如果一个动脉硬化不进展，那么它就不是一个对动脉硬化敏感的年轻人。然而，我们的方法甚至可以诊断出年轻的患者。此外，我们的方法有一个直观和定量的评估，可以估计，即使一个动脉硬化不是普通型。由于动脉无形态改变，该方法在动脉硬化的诊断中可能是有效的。较少

项目成果

Toshiaki Nagakura, Koji Masuda, Shinya Kosuge, Youko Hase, Yousuke Ooe et al.: "The non-invasive functional tissue characterization for arteriosclerosis by artery wall motion analysis with time series high-speed echo images and continuous spygmo-manometer

Toshiaki Nagakura、Koji Masuda、Shinya Kosuge、Youko Hase、Yousuke Ooe 等人：“通过时间序列高速回波图像和连续血压计进行动脉壁运动分析，对动脉硬化进行非侵入性功能组织表征

Toshiaki Nagakura,Koji Masuda,Shinya Kosuge,Youko Hase,Yoshihiro Shikata, et al.: "The Study For Arteriosclerosis By Using Functional Tissue Characterization with The New Visual and Quantitative Method"Ultrasound in Medicine and Biology,WFUMB. Abstracts.

Toshiaki Nagakura、Koji Masuda、Shinya Kosuge、Youko Hase、Yoshihiro Shikata 等人：“通过使用新的视觉和定量方法的功能组织表征来研究动脉硬化”超声医学和生物学，WFUMB。

長倉俊明,小菅進矢,岡田美香,長谷陽子,桝田晃司,吉野誠治,斉藤興治,石原謙 他: "循環器疾患診断支援システムの検討"第39回 日本エム・イー学会,医用電子と生体工学. 第38巻. 58-58 (2000)

Toshiaki Nagakura、Shinya Kosuge、Mika Okada、Yoko Hase、Koji Masuda、Seiji Yoshino、Koji Saito、Ken Ishihara等：“循环系统疾病诊断支持系统的研究”第39届日本MEE学会，医疗电子和生物工程第38卷。 58-58 (2000)

Toshiaki Nagakura, Koji Masuda, Shinya Kosuge, Youko Hase, Yousuke Ooe, et al.: "The Study of functional tissue characterization for arteriosclerosis estimated with continuous ultrasound image"Korea Society of Medical & Biological Engineering. 第2巻. 132-13

Toshiaki Nagakura、Koji Masuda、Shinya Kosuge、Youko Hase、Yousuke Ooe 等人：“用连续超声图像估计动脉硬化的功能组织特征研究”韩国医学与生物工程学会第 2 卷 132-13。

野上真子, 長倉俊明, 大江洋介, 楠岡英雄, 石原謙, 高橋秀也, 志水英二, 古川俊之: "多源視による定量的3次元画像の再構成の研究"第40回 日本エム・イー学会,医用電子と生体工学. 第39巻. 540-540 (2001)

Mako Nogami、Toshiaki Nagakura、Yosuke Oe、Hideo Kusuoka、Ken Ishihara、Hideya Takahashi、Eiji Shimizu、Toshiyuki Furukawa：“使用多源观察的定量三维图像重建研究”第 40 届日本 MEE 学会，医疗电子和生物工程卷。 39. 540-540 (2001)