The investigation into an intreretinal pathology and a molecular biological mechanism of diabetic retinopathy

点击翻译按钮获取中文摘要

Vascular endothelial growth factor (VEGF) mediates such ischemia-induced ocular neovascularization as diabetic retinopathy and age-related macular degeneration. In this research, we investigated the molecular mechanism how VEGF is highly expressed in retinas of diabetic retinopathy. Lectin-like oxidized LDL receptor 1(LOX1) is assume to play an important role in VEGF hyperexpression. We reveal a role for LOX1 in cell adhesion in endotoxin-induced inflammation. (PNAS2003 ; 4 ; 100 ; 3 ; 1274-9) Statin inhibits leucocyte-endothelial interaction and prevents neuroral death induced by ischemia-reperfusion injury in the rat retina, so statin has potential of therapeutic drug in diabetic retinopathy. (Arch Ophthal 2002 ; 120 ; 12 ; 1707-13). Leptin is known to be highly concentrated in blood and vitreous of diabetic patients. Leptin has angiogenic effect and we revealed that in ob/ob mice vascular proliferation is inhibited, and VEGF expression is inhibited. (in press) We revealed angiotensin potentiates the expression of VEGF receptor and angiopoietin 2. (Diabetes 2001 ; 50 ; 867-875) These effects are mediated by angiotensin type 1 receptor. These reveals a possibility that the control of molecular mechanism in LDL receptor, leptin, and angiotensin2 leads to inhibition of early change in diabetic retinopathy.