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Development of a multi-channel remote-recording system for analyzing neuronal activities of the central nervous system in freely behaving animals

开发多通道远程记录系统，用于分析自由行为动物中枢神经系统的神经元活动

基本信息

批准号：
13356004
负责人：
UEMATSU Kazumasa
金额：
$ 25.38万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

We aimed to develop a remote-recording system to acquire active potentials of multiple neurons in the brain of moving small animals including fish. Our final objective is identification of brain centers or systems integrating particular animal behavior, that is movements, emotion, learning and so on. For accomplish the object, we design a 1-chip LSI consisted of a wireless transceiver, a multiplexer, a chopper amplifier, an AD converter. After detailed simulations of several times, we designed each individual circuit and order to Education Center (VDEC) of the University of Tokyo to make the LSI. Each independent circuit on the prototype LSIs was tested individually to verify The VLSI Design and made order refined models in each year. The final model of LSI delivered during the research period worked well basically, but still with bugs in some individual circuits. A further refined LSI we had ordered is not delivered yet.In parallel to making the LSI, we made a special multiple electrode and succeeded in ideal recordings of action potential of particular neurons in the goldfish cerebellum. And we also ascertained that neuronal activities in moving fish could be recorded with implanted multiple-electrodes with wiresIt should be emphasized that this research projects was very significant in a point that it has accomplished by researchers in different department of the same university.

我们的目标是开发一个远程记录系统，以获取包括鱼类在内的运动小动物大脑中多个神经元的活动电位。我们的最终目标是识别大脑中心或系统集成特定的动物行为，即运动，情绪，学习等。为了实现这个目标，我们设计了一个单芯片的LSI，包括无线收发器，多路复用器，斩波放大器，AD转换器。经过多次详细的模拟，我们设计了每个单独的电路，并订购东京大学教育中心（VDEC）的LSI。每一个独立的电路原型LSI分别进行测试，以验证VLSI设计和订单细化模型在每年。在研究期间交付的LSI的最终模型基本上工作良好，但在一些个别电路中仍然存在缺陷。在制作LSI的同时，我们制作了一个特殊的多电极，成功地记录了金鱼小脑中特定神经元的动作电位。11同时，我们还证实了用植入的多电极导线可以记录运动鱼类的神经元活动。值得强调的是，这项研究项目是由同一所大学不同部门的研究人员共同完成的。