Regulation of osmoadaptation and Na+ homeostasis in Methanosarcina mazei Gö1
甲烷八叠球菌 Gö1 渗透适应和 Na 稳态的调节
基本信息
- 批准号:5314474
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Priority Programmes
- 财政年份:2001
- 资助国家:德国
- 起止时间:2000-12-31 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The first genomic sequence of a methylotrophic methanogen, Methanosarcina mazei Gö1, a halotolerant, metabolically versatile and genetically approachable methanogen, has been determined very recently. This offers a completely new strategy to study regulatory networks in methanogens on a global scale. Halotolerant methanogenic archaea accumulate compatible solutes and exclude Na+ from the cytoplasm upon increase of the external salt concentration. Unlike most other organisms, methanogens require a certain intracellular Na+ concentration for metabolic activity. To date, relatively little is known about the physiology of osmoadaptation and Na+ homeostasis, their regulation, their cross talk and cross talks with the regulatory networks involved in substrate utilization. The elucidation of these regulatory networks is the final goal of this project. At first we will concentrate on the elucidation of the physiology and regulation of the osmoresponse and Na+ homeostasis by biochemical and molecular techniques and the identification of the players involved in the networks by proteome analyses.
甲基营养型产甲烷菌Methanosarcina mazei Gö1的第一个基因组序列最近已被确定,它是一种耐盐的、代谢多样的和遗传上可接近的产甲烷菌。这为在全球范围内研究产甲烷菌的调控网络提供了一种全新的策略。耐盐的产甲烷古菌积累相容的溶质,并排除Na+从细胞质中的外部盐浓度的增加。与大多数其他生物不同,产甲烷菌需要一定的细胞内Na+浓度来进行代谢活动。到目前为止,相对知之甚少的生理学的适应和Na+稳态,他们的监管,他们的串扰和串扰与监管网络参与底物利用。阐明这些调控网络是本项目的最终目标。首先,我们将集中在阐明的生理学和调节的生理反应和Na+稳态的生物化学和分子技术和蛋白质组分析的参与网络的球员的识别。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Volker Müller其他文献
Professor Dr. Volker Müller的其他文献
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{{ truncateString('Professor Dr. Volker Müller', 18)}}的其他基金
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Research Grants
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- 批准号:
5303943 - 财政年份:2001
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Research Grants
Structure and function of ATP synthases from homoacetogenic bacteria and methanogenic archaea
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- 批准号:
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- 资助金额:
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Priority Programmes
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- 批准号:
503149329 - 财政年份:
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