Development of the flexible scaffolds of aortic stent grafts, which can be applied to the curvature repeatedly. -Also for application to the biodegradable stent grafts-

主动脉支架植入术是替代高风险的主动脉弓动脉瘤手术最有希望的方法之一，这种手术有时会导致悲剧。然而，我们需要克服一些问题，以适用于许多情况。由于移植物支架为刚性金属弹簧模式，难以调整到不能重复输送。在本研究中，我们尝试开发可反复施加曲率的主动脉支架柔性支架。这种新型支架由柔性管状气球制成，在液体的加压作用下，可以形成设计的形状。在不施加压力的情况下，支架可以折叠成直径较小的输送护套，并可进行分层输送。支架也可以在液体压力打开和关闭的情况下反复输送。当管球囊本身由可生物降解聚合物制成时，支架可以应用于可生物降解的支架移植物。支架模型在初步研究中成功成型。然而，最终，我们无法开发出足够坚固的支架来进行输送手术。我们得出结论，开发团队需要非常高的技术来制作管气球

Aortic stent grafting is one of the most promising alternatives to the high-risked aortic arch aneurysm operations, which sometimes result in the tragedies. However, we need to overcome some problems to apply to many cases. Since the scaffolds of the stent grafts are mode of stiff metal springs, it is difficult to adjust them to the cannot be delivered repeatedly. In this study, we tried to develop the flexible scaffolds of aortic stent grafts, which can be applied to the curvature repeatedly. The new scaffolds are made of flexible tube balloons, which can be formed the designed shape when they are pressurized by liquid. Without pressure, he scaffolds can be folded into the delivery sheaths with the small diameters, which can be delivered antegradely. The stent grafts also can be delivered repeatedly, with the liquid pressure on and off. The scaffold can be applied to the biodegradable stent grafts when the tube balloon itself is made of biodegradable polymers. The stent graft models were successful to be shaped as designed in the preliminary study. However finally, we were not able to develop the scaffolds strong enough for delivery operation. We concluded that developing team needed very high technology to from the tube balloons