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Experimental Study of Spinal Reconstruction Using Bioabsorbable Material

生物可吸收材料脊柱重建的实验研究

基本信息

批准号：
13671481
负责人：
ABUMI Kuniyoshi
金额：
$ 2.37万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

Objectives of the study were to evaluate the validity and advantage of forged composite of uncalcined hydroxyapatite Poly L-Lactite cage (F-u-HA/PLLA) radiographically, biomechanically, and histlogically when compared to conventional autologousiliac bone (AM) and carbon fiber cage (CFC). Twenty-five mature sheep underwent posterior lumbar interbody fusion at L2-3 level with pedide screw system. Three types of interbody fusion implants were grafted : AIB (n=7), CFC (n=9), F-u-HA/PLLA((n=9). Two types of cages were packed with autologous fragmented cancellous bone harvested locally. All animals were euthanized at 120 days after surgery. The fusion scoreing using the coronal view CT scans was designed to three dimentionally evaluate fusionquality within and around cages. The meen CT scores of threee groups were 33.3 points, 35.0 points, 33.6 points in AIB, CFC, and F-u-HA/PLLA cage groups, respectively (full-score : 56 points). Statistical differences were not detected among the three groups. The mean range of motion values among fused groups had no significant diffierence under all pure moment loadings. The range of motion showed strong and significant correlation with the CT fusion scores. Histologic results demonstrated that F-u-HA/PLLA cages contacted with the surrounding bone directly, and CFC was encircled with thick fibrous tissue layrs without any sign of inflammation around cages. The fusion quality of fused spinal segment using F-u-HA/PLLA cages was equal to that of AIB or CFC both radiographically and biomechanically. In the histological observation, biocompatibility of F-u-HA/PLLA cage was obviously superior to CFC. It has been confirmed that the novel bioactive and bioabsorbable cages had valuable advantages over existing CFC for use in spinal re constructive surgery.

该研究的目的是从放射学、生物力学和组织学角度评估未锻烧羟基磷灰石聚 L-乳石融合器 (F-u-HA/PLLA) 锻造复合材料与传统自体硅骨 (AM) 和碳纤维融合器 (CFC) 相比的有效性和优势。 25只成年羊采用足螺钉系统进行L2-3水平后路腰椎椎间融合术。移植三种类型的椎间融合植入物：AIB（n = 7），CFC（n = 9），F-u-HA / PLLA（（n = 9）。两种类型的融合器填充有本地采集的自体松质骨碎片。所有动物在术后120天处死。使用冠状位CT扫描的融合评分旨在从三个维度评估融合质量：笼子周围。 AIB组、CFC组、F-u-HA/PLLA笼组三组平均CT评分分别为33.3分、35.0分、33.6分（满分：56分）。三组之间未检测到统计学差异。在所有纯力矩载荷下，融合组之间的平均运动范围值没有显着差异。运动范围与 CT 表现出强烈且显着的相关性融合分数。组织学结果表明，F-u-HA/PLLA融合器与周围骨直接接触，CFC周围有厚厚的纤维组织层，融合器周围没有任何炎症迹象。使用F-u-HA/PLLA融合器的脊柱节段融合质量在放射学和生物力学上与AIB或CFC相同。在组织学观察中，生物相容性 F-u-HA/PLLA笼明显优于CFC。已经证实，新型生物活性和生物可吸收笼在脊柱重建手术中比现有的 CFC 具有宝贵的优势。

项目成果

期刊论文数量（49）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Multidirectional flexibility analysis of cervical artificial disc reconstruction : In vitro human cadaveric spinal model.

颈椎人工椎间盘重建的多向灵活性分析：体外人体尸体脊柱模型。

DOI：
发表时间：
2005
期刊：
J Neurosurg Spine 2
影响因子：
0
作者：
Kotani Y Cunningham BW;Abumi K;Dmitriew AE;Ito M;Hu Niabin;Shikinami Y;McAfee PC;Minami A
通讯作者：
Minami A

In vitro biomechanical effects of reconstruction on adjacent motion segment : comparison of aligned/kyphotic posterolateral fusion with aligned posterior lumbar interbody fusion/posterolateral fusion.

重建对相邻运动节段的体外生物力学影响：对齐/后凸后外侧融合与对齐后腰椎椎间融合/后外侧融合的比较。