Establishment and application of the quantitative analysis to the periodic and individual bone regenerative procedure

周期性个体骨再生过程定量分析的建立及应用

• 批准号: 13672076
• 负责人: KAMAKURA Shinji
• 金额: $ 2.18万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672076/
• 关键词: Bone; Bone Formation; Bone Regeneration; Octacalcium Phosphate; Calcium Phosphate

We have investigated the feasibility of the quantitative analysis to the bone regeneration by peripheral quantitative computed tomography (pQCT). The bone regenerative model was employed to the experimentally produced calvarial defect which is frequently applied for the analysis of osteoconductive biomaterials. Bone regeneration was inteasely reproduced by the quantitative analysis by pQCT. The quantitative analysis by pQCT have overcome a problem of the influence of soft tissue covered by the bone defect, which was unsolved by the formerly used methods. If radiopaque materials such as calcium phosphates compounds including octacalcium phosphate (OCP) was implanted in the calvarial defect, it had been difficult to distinguish the newly formed bone from the radiopaque materials. The analysis by pQCT has enabled to make a distinction between the newly formed bone and radiopaque materials such as calcium phosphates compounds. Therefore, it would be though that pQCT could respectively eval … More uate the newly formed bone formation and the resorption of the implant. The analysis by pQCT enables to examine the periodic and individual bone regenerative procedure. Consequently, the quantitative analysis to the bone regeneration by pQCT could be applied to the evaluation of other bone regenerative model.For the period of the research, undermentioned evidence was elucidated if the synthetic OCP is implanted into the cranial bone. OCP acts on osteoblasts and/or their closely committed progenitors and serve as a core for initiating bone formation. OCP is resorbed and replaced by newlv formed bone and enhances bone reeeneration. OCP is more resorbable than other commonly used bone graft substitutes of calcium phosphate compounds, while OCP enhances more bone formation than those compounds. As a scaffold of a cytokine, OCP synergically aihances bone regeneration. Above mentioned fruits was published by Journal of Biomedical Materials Research 57(2), 59(1), Oral Diseases 7(4), and Tohoku Univ Dent J 21(2). Less

探讨外周定量计算机断层扫描(PQCT)定量分析骨再生的可行性。骨再生模型被应用于实验产生的颅骨缺损，这是骨传导生物材料分析中经常使用的方法。PQCT定量分析显示骨再生完全重现。PQCT的定量分析克服了以往使用的方法不能解决的问题，即骨缺损对软组织的影响。如果在颅骨缺损处植入不透射线的材料，如磷酸钙化合物，包括磷酸八钙(OCP)，则很难区分新形成的骨和不透射线的材料。PQCT的分析使人们能够区分新形成的骨骼和不透射线的材料，如磷酸钙化合物。因此，尽管pQCT可以分别对…求值更重视新骨形成和种植体的吸收。通过pQCT的分析，可以检查周期性和个体化的骨再生过程。因此，pQCT对骨再生的定量分析可以应用于其他骨再生模型的评价。在研究期间，以下证据被阐明是否将合成的OCP植入颅骨内。OCP作用于成骨细胞和/或其紧密结合的祖细胞，是启动骨形成的核心。OCP被吸收，被新形成的骨取代，促进骨再生。OCP比其他常用的钙磷化合物的骨移植替代品更容易吸收，而OCP比那些化合物更能促进骨形成。作为一种细胞因子的支架，OCP协同促进骨再生。上述成果分别发表在《生物医学材料研究杂志》57(2)、59(1)、《口腔疾病》杂志7(4)和东北大学期刊J 21(2)上。较少

项目成果

Kamakura,S., Yamaguchi T., Kochi S., Sato A., Motegi K.: "Prdimimay report of two-stage secondary alveolar bone grafting for patients with bilateral cleft lip and palate"Cleft Palate-Craniofec J. in press. (2003)

Kamakura,S.、Yamaguchi T.、Kochi S.、Sato A.、Motegi K.：“双侧唇腭裂患者两阶段二次牙槽骨移植的 Prdimimay 报告”Cleft Palate-Craniofec J. 正在出版。

Kamakura S, et al.: "Implantation of octacalcium phosphate nucleates isolated bone formation in rat skull defects"Oral Dis. 7(4). 259-265 (2001)

Kamakura S 等人：“磷酸八钙的植入使大鼠颅骨缺损中的分离骨形成成核”Oral Dis。

Kamakura S.et al.: "Surgical and orthodontic management of compound odontoma without removal of the impacted permanent tooth"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 94. 540-542 (2002)

Kamakura S.等人：“复合牙瘤的手术和正畸治疗，无需去除受影响的恒牙”Oral Surg Oral Med Oral Pathol Oral Radiol Endod。

鎌倉慎治: "新しい骨再生療法の試み"東北大歯誌. 21. 75-86 (2002)

Shinji Kamakura：“新骨再生疗法的尝试”东北大学牙科杂志 21. 75-86 (2002)。

Kamakura S.et al.: "Surgical and orthodontic management of compound odontoma without removal of the impacted permanent tooth"Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod.. 94. 540-542 (2002)

Kamakura S.et al.：“不去除受影响恒牙的复合牙瘤的手术和正畸治疗”Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod.. 94. 540-542 (2002)