Pathophysiology of transneuronal degeneration in patients with cerebral infarcts investigated with molecular imaging methods

我们用正电子发射断层扫描测量了脑大动脉疾病和脑梗死患者的中枢苯二氮卓受体（cBZRs）。表现为cBZRs减少的神经元损伤不仅存在于未梗死的大脑皮层（可能是由于原发性缺血），也存在于丘脑（可能是由于跨神经元变性）。大脑皮层中cBZRs的减少与认知功能障碍有统计学意义的相关性，但丘脑中的cBZRs的减少与认知功能障碍没有统计学意义。

We measured the central benzodiazepine receptors (cBZRs) using positron emission tomography in patients with major cerebral artery disease and cerebral infarction. Neuronal damage manifested as a decrease in the cBZRs was found not only in the non-infarcted cerebral cortex, possibly through primary ischemia, but also in the thalamus, possibly through transneuronal degeneration. A decrease in the cBZRs in the cerebral cortex showed a statistically significant correlation with cognitive dysfunction but that in the thalamus did not.