Pathophysiology of transneuronal degeneration in patients with cerebral infarcts investigated with molecular imaging methods

我们用正电子发射断层扫描技术测定了脑动脉疾病和脑梗死患者的中枢苯二氮卓受体（cBZRs）。表现为cBZRs减少的神经元损伤不仅存在于非梗死的大脑皮层中（可能通过原发性缺血），而且存在于丘脑中（可能通过跨神经元变性）。大脑皮层中cBZRs的减少与认知功能障碍有统计学显著相关性，但丘脑中cBZRs的减少与认知功能障碍无统计学显著相关性。

We measured the central benzodiazepine receptors (cBZRs) using positron emission tomography in patients with major cerebral artery disease and cerebral infarction. Neuronal damage manifested as a decrease in the cBZRs was found not only in the non-infarcted cerebral cortex, possibly through primary ischemia, but also in the thalamus, possibly through transneuronal degeneration. A decrease in the cBZRs in the cerebral cortex showed a statistically significant correlation with cognitive dysfunction but that in the thalamus did not.