Clinical and epidemiological study on the endemic neurodegenerative diseases (parkinsonism-dementia complex : PDC) in the Kii peninsula of Japan, Guam island and Guadeloupe, French west Indies.

在2004年和2005年，我们访问了瓜德罗普，并检查了17个非典型的加勒比帕金森综合征患者的合作下，Lannuzel教授，瓜德罗普大学医院，并发现他们的特点是运动不能和额叶功能障碍，没有明显的僵硬，震颤，冻结，似乎是一个不同的实体从关岛和基伊半岛的PDC。在日本，被怀疑是导致该病的原因的番荔枝属植物的水果和草药茶不被食用。我们应邀参加了2005年12月2日至5日举行的“关岛和太平洋地区神经退行性疾病研讨会”，并就基伊半岛的ALS-PDC：临床、神经病理学和流行病学研究进行了讨论。讨论了关岛疾病和Kii疾病之间的异同和可能的原因。关岛的PDC和Kii的PDC可以包括在一个实体中。

In 2004 and 2005 we visited Guadeloupe, and examined 17 atypical Caribbean parkinsonism patients with a cooperation of professor Lannuzel, Guadeloupe University Hospital, and have found they were characterized by akinesia and frontal abulia without obvious rigidity, tremor, freezing, and seemed to be a different entity from PDC on Guam and Kii peninsula. Fruit and herb tea of Annona which are suspected as its cause are not consumed in Japan. We were invited to the "Neurodegenerative disorders on Guam and in the Pacific regions symposium" held on December 2-5, 2005, and talked on ALS-PDC in the Kii peninsula: clinical, neuropathological and epidemiological studies. Similarities and differences between Guamanian and Kii diseases and possible causes were discussed. PDC on Guam and PDC in Kii may be included in an entity.