Cell cycle and enteric neuron and glial differentiation

细胞周期与肠神经元和神经胶质分化

• 批准号: DP0345298
• 负责人: Prof Heather Young
• 金额: $ 7.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345298
• 关键词: Cell; cycle; enteric; neuron; glial

Enteric neurons arise from a very small starting population of precursor (neural crest) cells, most of which emigrate from the hindbrain, and colonise the developing gut. Over a protracted period of time the precursors proliferate and differentiate into glia and many different types of neurons. Cell cycle exit is a critical event in the development of many neuron types, largely because the time at which cells exit from the cell cycle limits the number of neurons that will be generated. We will determine whether exit from the cell cycle contributes to the differentiation and specification of enteric neurons and glia.

肠神经元起源于一个非常小的前体（神经嵴）细胞的起始种群，其中大部分从后脑迁移，并定居在发育中的肠道。经过一段漫长的时间，前体增殖并分化成胶质细胞和许多不同类型的神经元。在许多神经元类型的发育过程中，细胞周期退出是一个关键事件，主要是因为细胞退出细胞周期的时间限制了将产生的神经元数量。我们将确定细胞周期的退出是否有助于肠神经元和胶质细胞的分化和规范。