Migratory behaviour and cell cycle length of enteric neuron precursors

肠神经元前体的迁移行为和细胞周期长度

• 批准号: nhmrc : 628349
• 负责人: Prof Heather Young
• 金额: $ 31.49万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/migratory-behaviour-cell-neuron-precursors/94527
• 关键词: Migratory; behaviour; cell; cycle; length

The activity of nerves in the intestine is essential for gastrointestinal function. Correct development of intestinal neurons requires migration of precursors to the correct location and control of proliferation to achieve correct neuron number. In this project we will identify the mechanisms regulating migration and proliferation of intestinal neuron precursors during normal development, and in mice with defects in intestinal neurons that are models of human motility disorders.

肠道神经的活动对胃肠功能是必不可少的。肠道神经元的正确发育需要前体迁移到正确的位置并控制增殖，以获得正确的神经元数量。在这个项目中，我们将确定在正常发育过程中以及在肠道神经元缺陷小鼠中调节肠道神经元前体迁移和增殖的机制，这些缺陷是人类运动障碍的模型。