Neural migration: Which cells advance and which stay behind?

神经迁移：哪些细胞前进，哪些细胞落后？

• 批准号: DP150103709
• 负责人: Prof Heather Young
• 金额: $ 29.03万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103709
• 关键词: Neural; migration; cells; advance; stay

This project aims to examine the neural crest cells that colonise the developing gut and to identify why some cells advance while others stay behind to populate a region. Directed cell migration is essential for normal development, including for the nervous system. In most of the migratory cell populations that have been analysed to date, all of the cells migrate as a collective from one location to another. However, there are also migratory cell populations that must populate the areas through which they migrate, and thus some cells get left behind while others advance. The planned data are likely to be relevant to other cell populations that also populate the areas through which they migrate, including neural crest-derived melanocytes and Schwann cell precursors.

该项目旨在检查在发育中的肠道中定植的神经嵴细胞，并确定为什么一些细胞前进，而另一些细胞留在某个区域。定向细胞迁移对于正常发育至关重要，包括神经系统。 在迄今为止分析的大多数迁移细胞群体中，所有细胞都作为一个集体从一个位置迁移到另一个位置。然而，也有迁移细胞群必须填充它们迁移的区域，因此一些细胞在其他细胞前进时被留下。 计划的数据可能与其他细胞群相关，这些细胞群也分布在它们迁移的区域，包括神经嵴来源的黑素细胞和许旺细胞前体。