Development of the enteric nervous system

肠神经系统的发育

• 批准号: nhmrc : 1002506
• 负责人: Prof Heather Young
• 金额: $ 53.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-enteric-nervous/108822
• 关键词: Development; enteric; nervous; system

Gut motility requires enteric neurons, which are located in the gut wall. During development, enteric neurons arise from precursors in the brain that migrate into the intestine. Failure of enteric neuron precursors to migrate and differentiate normally results in pediatric motility disorders. The aim of this research is to identify the mechanisms controlling the development of enteric neurons so that therapies can be developed for pediatric motility disorders.

肠道运动需要位于肠壁中的肠神经元。在发育过程中，肠神经元来自大脑中迁移到肠中的前体。肠神经元前体细胞不能正常迁移和分化导致小儿运动障碍。本研究的目的是确定控制肠神经元发育的机制，以便为儿科动力障碍开发治疗方法。