权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neural mechanisms for suppression of saccades by the frontal eye field

额叶视野抑制眼跳的神经机制

基本信息

批准号：
16300131
负责人：
SHINODA Yoshikazu
金额：
$ 6.91万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300131/
关键词：
frontal eye field saccade fixation smooth pursuit eye movement

项目摘要

To understand the neural mechanism of fixation, we investigated effects of electrical stimulation of the frontal eye field (FEF) and its vicinity on visually guided (Vsacs) and memory-guided saccades (Msacs) in trained monkeys and found that there were two types of suppression induced by the electrical stimulation : suppression of ipsilateral saccades and suppression of bilateral saccades. In this report, we characterized the properties of the suppression of bilateral Vsacs and Msacs. Stimulation of the bilateral 'suppression sites suppressed the initiation of both Vsacs and Msacs in all directions during and 〜50ms after stimulation but did not affect the vector of these saccades. The suppression was stronger for ipsiversive larger saccades and contraversive smaller saccades, and saccades with initial eye positions shifted more in the saccadic direction. The most effective stimulation timing for the suppression of ipsilateral and contralateral Vsacs was 〜40-50ms before saccade onset, indicating that the suppression occurred most likely in the superior colliculus and/or the paramedian pontine reticular formation. Suppression sites of bilateral saccades were located in the prearcuate gyrus facing the inferior arcuate sulcus where stimulation induced suppression at 【less than or equal】40μA but usually did not evoke any saccades at 80μA and were different from those of ipsilateral saccades where stimulation evoked saccades at 【less than or equal】50μA The smooth pursuit area of the FEF was different from the bilateral suppression area. The bilateral suppression sites contained fixation neurons. The results suggest that fixation neurons in the bilateral suppression area of the FEF may play roles in maintaining fixation by suppressing saccades in all directions.

为了了解注视的神经机制，我们研究了电刺激额眼及其附近区域对训练猴视觉引导（Vsacs）和记忆引导扫视（Msacs）的影响，发现电刺激诱导的抑制有两种类型：抑制同侧扫视和抑制双侧扫视。在本报告中，我们描述了双侧Vsacs和Msacs的抑制特性。刺激双侧抑制部位在刺激后和刺激后约50ms内抑制了各方向的vsac和Msacs的启动，但不影响这些扫视的载体。对大扫视和小扫视的抑制更强，且初始眼位扫视更偏向于扫视方向。抑制同侧和对侧Vsacs最有效的刺激时间是在扫视开始前40-50ms，这表明抑制最可能发生在上丘和/或旁脉桥网状结构。双侧眼跳抑制部位位于面向下弓状沟的弓前回，刺激诱导的眼跳抑制在【小于等于】40μA，但通常不会诱发80μA的眼跳，与刺激诱发的【小于等于】50μA的同侧眼跳不同。FEF平滑追逐区与双侧抑制区不同。双侧抑制部位包含固定神经元。结果表明，双侧FEF抑制区的固定神经元可能通过抑制各方向的扫视来维持固定。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Long descending motor tract axons and their control of neck and axial muscles.

长的下降运动束轴突及其对颈部和轴向肌肉的控制。

DOI：
发表时间：
2005
期刊：
Progress in Brain Research 151
影响因子：
0
作者：
Sugihara;I.;那杰;Sugihara I;杉原泉;Sugiuchi Y;Takahashi M;Shinoda Y
通讯作者：
Shinoda Y

Commissural excitation and inhibition by the superior clliculus in tectoreticular neurons projecting to comnipause neuron and inhibitory burst neurons regions

投射到comnipause神经元和抑制性爆发神经元区域的顶盖神经元中上丛的连合兴奋和抑制

DOI：
发表时间：
2005
期刊：
J Neurophysiol 94
影响因子：
0
作者：
Khai Jun KEK;宮川崇拓;Takahiro MIYAKAWA;Khai Jun Kek;Khai Jun Kek;山本克之;Kengo OKADA;Khai Jun KEK;Kengo Okada;Satoshi Yamada;Nobuki Kudo;Khai Jun KEK;米山聡子;前川耕太;Khai Jun KEK;Nobuki KUDO;Satoko YONEYAMA;Koto MAEKAWA;Nobuki KUDO;米山聡子;Nobuki KUDO;Khai Jun KEK;Sugiuchi Y;Sugiuchi Y;Takahashi M;Izawa Y;Takahashi M
通讯作者：
Takahashi M

Vestibular projection to the periarcuate eortex and its relation to pursuit-related area in the monkey.

猴子的前庭投射到弓形周围皮质及其与追踪相关区域的关系。

DOI：
发表时间：
2005
期刊：
Annals of New York Academy of Science 1039(印刷中)
影响因子：
0
作者：
Moon;B.G.;Satoh K et al.;長谷川結子;Tomas Madura;青木美和;藤谷昌司;水野龍吉;田中裕之;Kawa S et al.;Suetsugu S. et al.;Morikatsu Yoshida 他11名;Zui Pan 他8名;Sugiuchi Y;Sugiuchi Y
通讯作者：
Sugiuchi Y

Commissural excitation and inhibition by the superior clliculus in tectoreticular neurons projecting to omnipause neuron and inhibitory burst neuron regions.

投射到全停神经元和抑制性爆发神经元区域的顶盖神经元中的上丛的连合兴奋和抑制。