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Research on Measuring Method of the Bone Stress by X-ray Diffraction properties of HAp Crystals in Living Bone Tissue

利用HAp晶体X射线衍射特性测量活骨组织骨应力方法的研究

基本信息

批准号：
16300143
负责人：
TADANO Shigeru
金额：
$ 9.41万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300143/
关键词：
Biomechanics Bone Structure X-ray Diffraction Stress Measurements Imaging Plate Residual Stress HAp Crystal Strain Bone Stress バイオメカニズム解析X線解析波形形態法

项目摘要

Cortical Bone is a composite material composed of hydroxyapatite (HAp) and collagen. As HAp is a crystalline structure, an X-ray diffraction method is available to measure the strain of HAp crystals. However, HAp crystals in bone tissue have been known to have the low degree of crystallization. X-ray diffraction method was proposed to measure the lattice strain of HAp crystals from the diffusive intensity profile due to low crystallinity. Also, in order to estimate the bone tissue strain with measurements of the strain of HAp crystals, this work investigates the relationship between bone tissue strain on a macroscopic scale and the lattice strain of HAp crystals on a microscopic scale. The X-ray diffraction experiments were performed under tensile loading. Strip bone specimens of 40x6x0.8 mm in size were cut from the cortical region of a shaft of bovine femur. By detecting the diffracted X-ray beam transmitted through the specimen, the lattice strain was directly measured in the loadin … More g direction. Three lattice strains at each lattice planes (002), (211) and (213) in the HAp crystals were measured by the X-ray diffraction system. The strain was calculated from the X-ray diffraction profiles at the non-strained and the strained state. All lattice strain increased linearly with the bone tissue strain and was everywhere lower than the bone tissue strain. The values of mean lattice strain increase linearly with the bone tissue strain. The mean strain ratio (mean lattice strain/ tissue strain) was higher for bone axial specimen. This tendency agreed with the differences in the elastic modulus of specimens. The lattice strain of HAp crystals aligned with a loading direction was obtained directly from diffracted and transmitted X-ray beams measured after penetration of cortical bone specimens under tensile loading. The lattice strain was lower than the macroscopic bone tissue strain in all specimens and higher for specimens with higher elastic modulus under similar macroscopic strains. The bone tissue strain could be estimated from the lattice strain calculated for the whole profile and the elastic modulus of the bone tissue. Less

皮质骨是由羟基磷灰石（HAp）和胶原蛋白组成的复合材料。由于HAp是晶体结构，因此可以使用X射线衍射方法来测量HAp晶体的应变。然而，已知骨组织中的 HAp 晶体的结晶度较低。由于结晶度低，因此提出了 X 射线衍射方法来根据扩散强度分布来测量 HAp 晶体的晶格应变。此外，为了通过测量HAp晶体的应变来估计骨组织应变，本工作研究了宏观尺度上的骨组织应变与微观尺度上的HAp晶体的晶格应变之间的关系。 X射线衍射实验在拉伸载荷下进行。从牛股骨干的皮质区域切下尺寸为 40x6x0.8 mm 的条状骨标本。通过检测穿过样品的衍射 X 射线束，直接测量载荷 g 方向上的晶格应变。通过X射线衍射系统测量了HAp晶体中每个晶格面（002）、（211）和（213）处的三个晶格应变。根据非应变和应变状态下的 X 射线衍射图计算应变。所有晶格应变均随骨组织应变线性增加，并且各处均低于骨组织应变。平均晶格应变值随骨组织应变线性增加。骨轴向样本的平均应变比（平均晶格应变/组织应变）较高。这种趋势与样本弹性模量的差异一致。与加载方向对齐的 HAp 晶体的晶格应变是直接从在拉伸载荷下穿透皮质骨样本后测量的衍射和透射 X 射线束获得的。所有标本的晶格应变均低于宏观骨组织应变，而在相似的宏观应变下，弹性模量较高的标本的晶格应变较高。骨组织应变可以根据为整个轮廓计算的晶格应变和骨组织的弹性模量来估计。较少的

项目成果

期刊论文数量（34）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Relationship between Macro Strain and Lattice Strain of Hydroxyapatite in Bone Tissue

骨组织中羟基磷灰石宏观应变与晶格应变的关系

DOI：
发表时间：
2004
期刊：
Proceedings of SEM X International Congress ＆ Exposition on Experimental and Applied Mechanics (CD-ROM)
影响因子：
0
作者：
M.Todoh;S.Tadano;K.Fujisaki;T.Kanamori;K.Fujisaki;S.Tadano
通讯作者：
S.Tadano

A Method on Strain Measurement of HAp in Cortical Bone from Diffusive Profile of X-ray Diffraction

从X射线衍射漫射剖面测量皮质骨HAp应变的方法

DOI：
发表时间：
2006
期刊：
Journal of Biomechanics 39・3
影响因子：
0
作者：
K.Fujisaki;S.Tadano;S.Tadano;K.Fujisaki
通讯作者：
K.Fujisaki

Bone Tissue Strain and Lattice Strain of HAp Crystals under Tensile Loading

拉伸载荷下HAp晶体的骨组织应变和晶格应变

DOI：
发表时间：
2004
期刊：
Proceedings of IMECE 2004 : ASME International Mechanical Engineering Congress and RD＆D Expo (CD-ROM) Vol.1
影响因子：
0
作者：
M.Todoh;S.Tadano;K.Fujisaki;T.Kanamori;K.Fujisaki
通讯作者：
K.Fujisaki

Relationshop between Elastic Modulus and Lattice Strain of HAP Crystals in Bovine Conrtical Bone

牛圆锥体HAP晶体弹性模量与晶格应变的关系

DOI：
发表时间：
2004
期刊：
Proceedings of First Asian Pacific Conference on Biomechanics
影响因子：
0
作者：
K.Fujisaki;S.Tadano;J.Shibano;N.Sasaki
通讯作者：
N.Sasaki

Microstructure of Bone around Natural Holen in Bovine Lumbar Vertebra

牛腰椎天然孔周围骨的显微结构

DOI：
发表时间：
2007
期刊：
Journal of Biomechanical Science and Engineering 2・1
影响因子：
0
作者：
Miyagishi;M.;Sumimoto;H.;Miyoshi;H.;Kawakami Y.;Taira;K.;Suzuki O;鈴木義之;Suzuki O et al.;Suzuki Y et al.;Suzuki O et al.;Noguchi A;Noguchi A et al.;Noguchi A et al.;Ito J.;Ito J.;Ito J.;Hirabayashi M.;Iwanami Y.;Ito J.;Ito J.;Hirabayashi M.;Ito J;Ito J.;Hirabayashi M.;Ito J.;Hirabayashi M.;Hirabayashi M.;Ito J.;Kato M.;Ito J.;Ito J.;Hirabayashi M.;Hirabayashi M.;Bijay Giri
通讯作者：
Bijay Giri