System Biology Model for Tumor Radiotherapy

本研究旨在提出一种计算模拟方法来计算放射治疗的疗效，并应用系统生物学的方法。当肿瘤由于辐射照射而缩小时，可以用肿瘤体积变化和几何畸变来表示辐射效应。收缩被认为是固体力学相似性的表现。从固体力学方程出发，估算了辐射能量与肿瘤形变之间的关系。基于计算机断层扫描（CT）图像构建肿瘤的有限元模型。确定了肿瘤放射敏感性或肿瘤细胞生长速率的某些参数值，使计算结果与临床结果相吻合。仿真结果表明，通过合理确定肿瘤参数，该仿真模型可以应用于各种临床病例.

This study is to propose a computational simulation method to calculate therapeuticoutcomes in radiotherapy, and also applied a method of system biology. As a tumor shrinksdue to radiation exposure, it was possible to express the radiotherapeutic effects in terms oftumor volume changes and geometric distortion. The shrinking was assumed to expressmechanical analogy of solid body. The relationships between radiation energy and tumordeformation were estimated from solid mechanics equations. Finite element models oftumors were constructed based on computed tomography (CT) images. Some values ofparameters prescribing tumor radiosensitivity or growth rates of tumor cells wereidentified so that the calculated results fit the clinical results. Simulation results will showthat the simulation model can be applied to a variety of clinical cases by determining thetumor parameters appropriately.