Establishment of diagnostic and treatment strategies for chronic fatigue syndrome

慢性疲劳综合征诊断和治疗策略的建立

• 批准号: 16390199
• 负责人: BAN Nobutaro
• 金额: $ 8万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390199/
• 关键词: fatigue; chronic fatigue; dia gnosis; treatment; cDNA chip; microarray; Q fever; HHV; 慢性; 漢方; HHV6; HHV7

We performed the following investigations to explore unknown mechanism underling the chronic fatigue syndrome (CFS) syndrome and to find tools for objective assessment from 2004 to 2006.SUBJECTS : Sixty patients with the chief complaint of general fatigueMEASUREMENTS: Clinical information, laboratory data including serum hormones and antibodies against human herpes viruses (HHV 6 and 7) or Coxiella burnetti, and mRNA expression of stress-responsive genes in peripheral blood cells.MPARTICIPTED CLINICIANS: All patients were clinical assessed by general internists as well as psychiatrist.TREATMENTS: All patients were treated by traditional herbal medicine according to the patients clinical conditions ‘Sho'.RESULTS:1) Increased HHV6 and HHV7 titers were noted in 4 patients, but they were not particularly related with CFS.2) No patient showed the increased antibodies against Coxiella burnetti.3) Clinically patients with the chief complaint of general fatigue were divided into 4 groups: CFS, psychiatric disease, organic disease, and undetermined etiology. Amongst 26 patients who were fully investigated CFS 8 cases, psychiatric disease 11 cases, organic disease 4 cases, and undetermined etiology 3 cases.4) Nine genes that may be useful for detection of pathological responses in CFS patients and for differential diagnosis of this syndrome were determined.5) ‘Sho' did not shoe any particular pattern.

从2004年到2006年，我们进行了以下调查，以探索慢性疲劳综合征(CFS)综合征的未知机制，并寻找客观评估的工具。材料：60例以全身疲劳为主诉的患者的临床资料、实验室资料，包括血清激素和抗人类疱疹病毒(HHV)6和7或柯萨奇病毒(Coxiella Burnetti)抗体，以及外周血细胞应激反应基因的mRNA表达。3)临床上以全身乏力为主诉的患者分为4组：慢性疲劳综合征组、精神疾病组、器质性疾病组和病因不明组。在26例全面调查的患者中，8例为CFS，11例为精神疾病，4例为器质性疾病，3例病因不明。4)确定了9个可用于检测CFS患者的病理反应和鉴别诊断本综合征的基因。

项目成果

疲労・倦怠感を主訴とする患者に対する診断の手引き.

针对主要主诉为疲劳和不适的患者的诊断指南。

• 发表时间: 2006
• 期刊: 総合臨床 55
• 作者: 伴信太郎

Stress and neuro-endocrine network. (in Japanese)

压力和神经内分泌网络。

• 发表时间: 2005
• 期刊: Brain and Nerve 57
• 作者: Kyoko Morita;Kazuhito Rokutan;et al.
• 通讯作者: et al.

How to evaluate the patients with general fatigue. (in Japanese)

如何评估全身疲劳患者。

• 发表时间: 2006
• 期刊: Psychosomatic medicine 10
• 作者: Takuya Saiki;Nobutaro Ban
• 通讯作者: Nobutaro Ban

Development of new stress assessment methods and its clinical application. (in Japanese)

新型压力评估方法的开发及其临床应用。

• 发表时间: 2006
• 期刊: Gout and Nucleic Acid Metabolism 30
• 作者: Kyoko Morita;Kazuhito Rokutan;et al.;Kazuhito Rokutan
• 通讯作者: Kazuhito Rokutan

慢性疲労症候群の診断方法

如何诊断慢性疲劳综合症

• 发表时间: 2006