Establishment of diagnostic and treatment strategies for chronic fatigue syndrome

慢性疲劳综合征诊断和治疗策略的建立

基本信息

批准号：
16390199
负责人：
BAN Nobutaro
金额：
$ 8万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390199/
关键词：
fatigue chronic fatigue dia gnosis treatment cDNA chip microarray Q fever HHV 慢性漢方 HHV6 HHV7

项目摘要

We performed the following investigations to explore unknown mechanism underling the chronic fatigue syndrome (CFS) syndrome and to find tools for objective assessment from 2004 to 2006.SUBJECTS : Sixty patients with the chief complaint of general fatigueMEASUREMENTS: Clinical information, laboratory data including serum hormones and antibodies against human herpes viruses (HHV 6 and 7) or Coxiella burnetti, and mRNA expression of stress-responsive genes in peripheral blood cells.MPARTICIPTED CLINICIANS: All patients were clinical assessed by general internists as well as psychiatrist.TREATMENTS: All patients were treated by traditional herbal medicine according to the patients clinical conditions ‘Sho'.RESULTS:1) Increased HHV6 and HHV7 titers were noted in 4 patients, but they were not particularly related with CFS.2) No patient showed the increased antibodies against Coxiella burnetti.3) Clinically patients with the chief complaint of general fatigue were divided into 4 groups: CFS, psychiatric disease, organic disease, and undetermined etiology. Amongst 26 patients who were fully investigated CFS 8 cases, psychiatric disease 11 cases, organic disease 4 cases, and undetermined etiology 3 cases.4) Nine genes that may be useful for detection of pathological responses in CFS patients and for differential diagnosis of this syndrome were determined.5) ‘Sho' did not shoe any particular pattern.

We performed the following investigations to explore unknown mechanism underling the chronic fatigue syndrome (CFS) syndrome and to find tools for objective assessment from 2004 to 2006.SUBJECTS: Sixty patients with the chief complaints of general fatigueMEASUREMENTS: Clinical information, laboratory data including serum horses and antibodies against human herpes viruses (HHV 6 and 7) or Coxiella burnetti, and mRNA expression of周围血细胞中的压力响应性基因。参与的临床医生：所有患者均经过一般的内在疗法和精神病医生对临床评估。治疗：所有患者均接受了传统草药的治疗。根据患者的临床状况，根据“ SHO”的临床状况“ SHO”。疾病：1）与HHV6和HHV7山雀相关的患者并未与HHV7山雀相关，但与HHV7山雀相关，他们对CF没有任何相关性。针对Coxiella burnetti.3）临床上患有一般疲劳的主要投诉的患者分为4组：CFS，精神病，有机疾病和不确定的病因。在26例经过全面研究的患者中，在CFS 8病例中，精神病病11例，有机疾病4例和未确定的病因3病例。4）9个基因可能有助于检测CFS患者的病理反应以及该综合征的差异诊断。