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Cancer diagnosis with Positron Emission Tomography ; Development of a new tyrosine analogue

正电子发射断层扫描癌症诊断；

基本信息

批准号：
16390349
负责人：
KUBOTA Kazuo
金额：
$ 7.44万
依托单位：
International Medical Center of Japan
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

项目摘要

The aim of study is the development of a new amino acid analogue O-[11C]methyl-L-tyrosine (OMT) and its first clinical application to whole-body imaging as well as brain tumor imaging. OMT was firstly prepared with a high radiochemical yield by the methylation of L-tyrosine with [^<11>C]methyl triflate followed by HPLC purification (Iwata et al., 2002). Later, the simple automated method using the solid phase extraction without HPLC purification was developed for routine clinical use (Ishikawa et al., 2005).Seventeen patients (13 male, 4 female, mean age 69, range 46-89) of various types of cancer or suspected of cancer with 24 lesions were studied with OMT-PET. Sixteen patients have been studied with FDG-PET also within a week.Diagnostic accuracy for all lesions were calculated as follows : sensitivity of OMT 75% (12/16) and FDG 94% (15/16) ; specificity of OMT 75% (6/8) and FDG 43% (3/7) ; and accuracy of OMT 75% (18/24) and FDG 78% (18/23). Chronic xantomatous cholecystitis showed r … More ing like uptake with FDG, but no significant uptake with OMT. Tumor to background ratios (T/B ratios) of lung cancer and brain tumor were around 2.0. Mean SUV values of malignant and benign lesions with OMT-PET and FDG-PET were as follows : OMT malignant 2.26±1.44 (n=16), OMT benign 2.25±1.33 (n=8), FDG malignant 5.98±3.38 (n=16), FDG benign 4.79±2.64 (n=7). There were no significant differences between malignant and benign neither with FDG nor OMT.As the normal distribution, liver and pancreas uptake of OMT was mild, but urinary excretion was observed from early after injection. Normal brain uptake was lower than the liver, and slightly higher than the muscle. Kidney and urine in the bladder showed the highest activity. Results were summarized as follows;1. OMT uptake by tumor was tended lower than the FDG.2. OMT uptake by inflammation was tended lower than the FDG.3. In some tumors, such as esophageal cancer, gall bladder cancer, OMT-PET may be helpful to avoid false positive results that was derived by FDG uptake of active inflammation. Less

研究的目的是开发一种新的氨基酸类似物O-[11 C]甲基-L-酪氨酸（OMT），并将其首次应用于全身成像和脑肿瘤成像。OMT首先通过用[13 C]三氟甲磺酸甲酯甲基化L-酪氨酸，然后通过HPLC纯化以高放射化学产率制备<11>（岩田等人，2002年）。后来，开发了使用固相萃取而无需HPLC纯化的简单自动化方法用于常规临床应用（石川等人，2005). 17例不同类型癌症或疑似癌症的患者（13例男性，4例女性，平均年龄69岁，范围46-89）进行了OMT-PET研究，共24个病灶。16例患者在1周内进行了FDG-PET检查，其诊断准确性分别为：OMT敏感性75%（12/16）和FDG 94%（15/16），特异性75%（6/8）和FDG 43%（3/7），准确性75%（18/24）和FDG 78%（18/23）。慢性黄色瘤性胆囊炎显示r ...更多信息 FDG摄取类似，但OMT摄取不明显。肺癌和脑肿瘤的肿瘤与背景比值（T/B比值）约为2.0。OMT PET和FDG PET诊断恶性和良性病变的SUV值分别为：OMT恶性2.26±1.44（n=16），OMT良性2.25±1.33（n=8），FDG恶性5.98±3.38（n=16），FDG良性4.79±2.64（n=7）。肝脏和胰腺对OMT的摄取呈轻度正态分布，但从注射后早期就开始有尿液排泄。正常脑摄取低于肝脏，略高于肌肉。肾脏和膀胱中的尿液显示出最高的活性。研究结果如下：1.肿瘤对OMT的摄取有低于FDG的趋势.炎症对OMT的摄取有低于FDG的趋势.在某些肿瘤中，如食管癌、胆囊癌，OMT-PET可能有助于避免由FDG摄取引起的假阳性结果。少