The development of the prophylactic by the vaccine for stomatitis caused by Candida induced by the use of denture in elderlies who need care

老年人因戴假牙引起的念珠菌性口腔炎预防剂的研制

• 批准号: 17592033
• 负责人: NAGAMATSU Hiroshi
• 金额: $ 2.24万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17592033/
• 关键词: Candida albicans; inoculation; mycelia; oral mucosa; C.albicans; 口腔カンジダ症; 唾液抗体; 分泌型IgA; 口蓋扁桃; ウサギ; 感染

To obtain a model of asymptomatic oral carriers, non-treated rabbits were orally inoculated with small number of Candida albicans. Colony-forming units of C. albicans in daily oral swab samples increased and stayed at high levels in a week without causing white patches on oral mucosa. Although fungal filaments were found within the cornified layer of oral mucosa in thin sections, the accumulation of the inflammatory cells was not found in the surrounding tissues. Anti-C. albicans IgG as the sign of infection was induced in serum of some rabbits having greater than 500 CFU of the average C. albicans CFU in swab sample, but the antibodies did not induce those less than 150 CFU. We proposed the hypothesis of the cell density dependent model for the transition to the infection from oral carrier of C. albicans.

为了获得无症状口腔携带者的模型，将少量白色念珠菌经口接种于未处理的兔。C.每日口腔拭子样本中的白色念珠菌增加，并在一周内保持在高水平，而不会导致口腔粘膜出现白色斑块。虽然在薄切片中在口腔粘膜的皮质层内发现真菌丝，但在周围组织中未发现炎性细胞的积聚。抗C在部分家兔的血清中诱导出白色念珠菌IgG作为感染的标志，其平均菌落数大于500 CFU。白念珠菌的抗体对低于150 CFU的白念珠菌无诱导作用。提出了口腔携带者向感染转化的细胞密度依赖模型假说。白色念珠菌。

项目成果

Cell density-dependent infection of Candida albicans after inoculation of small number the fungi in Non-Treated Rabbits

未经治疗的兔子接种少量真菌后白色念珠菌的细胞密度依赖性感染

• 期刊: FEMS Immunology & Medical Microbiology (getting ready to contribute)
• 作者: H.Inoue;H.Nagamatsu;Yuji Seta;Tatsuro Kojo
• 通讯作者: Tatsuro Kojo