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Alpha-Synuclein Inoculation in Anterior Olfactory Nucleus and its Effects on Olfactory Function in Prodromal Parkinson’s Disease

Alpha-Synuclein Inoculation in Anterior Olfactory Nucleus and its Effects on Olfactory Function in Prodromal Parkinson’s Disease
前嗅核中接种 α-突触核蛋白及其对帕金森病前驱期嗅觉功能的影响
批准号：
486247
负责人：
Tran Ruth
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-12-01 至 2023-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486247&lang=en
关键词：
Alpha-Synuclein Anterior Olfactory Nucleus Hippocampus Neuroinflammation Olfactory Dysfunction Olfactory Memory Olfactory Sensitivity Olfactory Vector Hypothesis Parkinson'S Disease Prodromal Parkinson'S Disease

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英文摘要
Hyposmia, an impaired sense of smell, is a prevalent non-motor symptom that occurs early in Parkinson's Disease (PD), preceding classic motor symptoms by at least 4 years. Alpha-synuclein (a-syn), the pathological protein aggregates implicated in PD, are
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