DEVELOPMENT AND CLINICAL APPLICATION OF IMPLANTABLE WEARABLE ARTIFICIAL ENDOCRINE PANCREAS WITH A TELEMETRY GLUCOSE MONITORING SYSTEM

为了连续监测动态糖尿病患者的血糖浓度，研制了一种针式血糖传感器遥测血糖监测系统。该系统由传感器发射器和接收器组成，传感器发射器将针型血糖传感器产生的电流信号转换为高频音频信号，接收器根据接收的音频信号连续计算葡萄糖浓度。变送器由电流-电压转换放大器、电压-频率转换器和电池组成。接收器将音频信号解调成电压，并根据该电压计算出的葡萄糖浓度持续显示在LED显示器上。超过预先设定的阈值的高血糖或低血糖由声音发出警报。该接收机由甚高频振荡器、频率调制器、电子滤波器、频率-电压转换器、报警电路和电池组成。接收器在发射器周围20m范围内捕获传感器信号。遥测系统的监测记录的噪声范围小于有线遥测系统--可穿戴式人工内分泌胰腺。正常动物的连续血糖监测显示，皮下组织葡萄糖浓度与同时测量的每只动物的血糖浓度之间存在显著的相关性。这些数据表明和暗示了LE遥测血糖监测系统在糖尿病患者血糖控制中的有效性。

For continuous monitoring glucose concentration in ambulant diabetic patients, a telemetry glucose monitoring system with a needle-type glucose sensor has been developed. The system consists of a sensor transmitter that converts current signals generated in a needle-type glucose sensor to high-frequency audio-signals and receiver that continuously calculates glucose concentrations from the received audio signals. The transmitter, packed with a current-voltage-converting amplifier, a voltage-frequency converter, and a battery. The receiver demodulates the audiofrequency signal to a voltage and the glucose concentration calculated from the voltage is continuously displayed in the LED display. Hyperglycemia or hypoglycemia beyond the prefixed threshold is alarmed by sound. The receiver is composed of a VHF oscillator, a frequency modulator, electric filters, a frequency-voltage converter, and an alarm circuit and batteries. The receiver catches the sensor signal within 20 m of the transmitter.The noise range of a monitoring record with the telemetry system was smaller than that with a wire-connected telemetry system, the wearable artificial endocrine pancreas.Continuous glucose monitoring of normal animal subjects revealed that a significant correlation existed between the subcutaneous tissue glucose concentration and the plasma glucose concentration measured simultaneously in each animal.These data indicate and suggest the usefulness of le telemetry glucose monitoring system in glycemic control of diabetic individuals.