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DEVELOPMENT AND CLINICAL APPLICATION OF IMPLANTABLE WEARABLE ARTIFICIAL ENDOCRINE PANCREAS WITH A TELEMETRY GLUCOSE MONITORING SYSTEM

具有遥测血糖监测系统的植入式可穿戴人工内分泌胰腺的开发和临床应用

基本信息

批准号：
10680798
负责人：
SAKAKIDA Michiharu
金额：
$ 2.3万
依托单位：
KUMAMOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

For continuous monitoring glucose concentration in ambulant diabetic patients, a telemetry glucose monitoring system with a needle-type glucose sensor has been developed. The system consists of a sensor transmitter that converts current signals generated in a needle-type glucose sensor to high-frequency audio-signals and receiver that continuously calculates glucose concentrations from the received audio signals. The transmitter, packed with a current-voltage-converting amplifier, a voltage-frequency converter, and a battery. The receiver demodulates the audiofrequency signal to a voltage and the glucose concentration calculated from the voltage is continuously displayed in the LED display. Hyperglycemia or hypoglycemia beyond the prefixed threshold is alarmed by sound. The receiver is composed of a VHF oscillator, a frequency modulator, electric filters, a frequency-voltage converter, and an alarm circuit and batteries. The receiver catches the sensor signal within 20 m of the transmitter.The noise range of a monitoring record with the telemetry system was smaller than that with a wire-connected telemetry system, the wearable artificial endocrine pancreas.Continuous glucose monitoring of normal animal subjects revealed that a significant correlation existed between the subcutaneous tissue glucose concentration and the plasma glucose concentration measured simultaneously in each animal.These data indicate and suggest the usefulness of le telemetry glucose monitoring system in glycemic control of diabetic individuals.

为连续监测非卧床糖尿病患者的血糖浓度，研制了一种带针式血糖传感器的遥测血糖监测系统。该系统由传感器发送器和接收器组成，传感器发送器将针型葡萄糖传感器中产生的电流信号转换为高频音频信号，接收器根据接收到的音频信号连续计算葡萄糖浓度。发射机，装有电流-电压转换放大器，电压-频率转换器和电池。接收器将听觉信号转换为电压，并且从电压计算的葡萄糖浓度连续地显示在LED显示器中。高血糖或低血糖超过预设阈值时会发出声音报警。接收机由甚高频振荡器、调频器、滤波器、频压转换器、报警电路和电池组成。接收机在距离发射机20 m范围内接收传感器信号，遥测系统监测记录的噪声范围小于有线遥测系统，可穿戴人工内分泌胰腺。正常动物受试者的连续葡萄糖监测显示，皮下组织葡萄糖浓度与同时测量的血浆葡萄糖浓度之间存在显著相关性，这些数据表明并提示遥测血糖监测系统在糖尿病个体的血糖控制中的有用性。