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SEARCH FOR BIOFUNCTIONAL SAPONINS AND THEIR MECHANISMS OF ACTION

寻找生物功能皂苷及其作用机制

基本信息

批准号：
18510194
负责人：
MATSUDA Hisashi
金额：
$ 2.63万
依托单位：
Kyoto Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

In the present study, various pharmacological effects of medicinal herbs which have been used as antidaiabetes, antiinflammation, tonic were examined. Among them, bioactive saponins were isolated and their chemical structures were elucidated on the basis of chemical and physicochemical evidence. Structural requirements of the active saponins for the bioactivities and mechanisms of action were clarified in part.Five new cucurbitane-type triterpenes, karavilagenins and ten new cucurbitane-type triterpene saponins, karavilosides, were isolated from the dried fruit of Sri Lanka Momordica charantica with anti-diabetic effects and their chemical structures were determined. The major steroidal alkaloid saponins, solamargine and solasonine, from the fruit of Solanaum lycocarpum cultivated in Brazil showed gastroprotections in rats and were found to inhibit the increase in blood glucose levels in sucrose-loaded rats. The methanolic extract from flower of Borassus flabrllifera collected in Thail … More and and its principal constituent, dioscin, showed anti-hyperglycemic effects and chemical structures of six new spirostane-type steroidal saponins, borassosides, were determined. From the fruit of Citrullus colocynthis, cucurbitacin E and its glycosides were isolated as laxative and anti-allergic principles together with the chemical determination of two new cucurbitane-type triterpene saponins. The major saponis from the flower buds of Panax ginseng were found to show gastroprotective effects in rats and seventeen new dammarane-type triterpene saponins, floralginsenosides, were isolated and their chemical structures were determined. New biofunctional effects of flowers of Bellis perennis and Camellia sinensis were examined, and enhancement of gastrointestinal transit and inhibition of absorption of triglycerides, etc. New saponins perennisaponins, floratheasaponins and chakasaponins were isolated as the active constituents and their chemical structures were determined. With regard to mechanism of the inhibition of absorption of triglycerides, inhibitions of pancreatic lipase activity and gastric emptying are involved in their effects. Less

本研究对近年来被广泛应用的抗糖尿病、抗炎、滋补等中草药的药理作用进行了研究。其中，活性皂苷的分离和化学和理化证据的基础上，其化学结构进行了鉴定。部分阐明了活性皂苷生物活性的结构要求和作用机制，从具有抗糖尿病作用的斯里兰卡苦瓜干果中分离得到5个新的葫芦烷型三萜苷元（karavilagenins）和10个新的葫芦烷型三萜皂苷（karavilosides），并确定了它们的化学结构。主要的甾体生物碱皂苷，solamargine和solasalphine，从果实的茄在巴西栽培lycocarpum显示胃保护大鼠，并发现抑制血糖水平的增加，在蔗糖负荷的大鼠。泰国产扁叶硼树花的甲醇提取物 ...更多信息其主要成分薯蓣皂苷具有降血糖作用，并测定了6个新的螺甾烷型甾体皂苷borassosides的化学结构。从西瓜（Citrullus colocynthis）果实中分离得到具有通便和抗过敏作用的葫芦素E（Cucurbitacin E）及其苷类化合物，并对两个新的葫芦烷型三萜皂苷进行了化学鉴定。从人参花蕾中分离得到17个新的达玛烷型三萜皂苷类化合物，即花旗参皂苷，并测定了它们的化学结构。研究了多年生植物Bellisperennis和茶树花的新生物功能，包括促进胃肠转运和抑制甘油三酯吸收等。分离得到了多年生植物新皂苷，floratheasaponins和chakasaponins，并确定了它们的化学结构。关于抑制甘油三酯吸收的机制，其作用涉及抑制胰脂肪酶活性和胃排空。少