Development of New Ionizations Technique such as SIMS, FAB and FD and Mass Spectrometry of Biomedical Substance.

SIMS、FAB、FD等新型电离技术的开发以及生物医学物质的质谱分析。

• 批准号: 59390017
• 负责人: MATSUDA Hisashi
• 金额: $ 3.07万
• 依托单位: College of General Education, Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1984
• 资助国家: 日本
• 起止时间: 1984 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-59390017/
• 关键词: SIMS; FAB; FD; Mass Spectrometry; Soft Ionization; Peptide; Cluster Ion; イオンガン

1. Mass Spectrometry of Biomedical Highmass SubstanceIn beam technique was introduced by Ohashi. The behaviour of Na ion in the SIMS ionization was investigated by Suzuki. Matsuo, Katakuse and Matsuda established the technique to analyze the hemoglobin variants, and determined several new structure of variants. They also measured the mass distribution in the mass spectrum of peptide. Ikekawa investigated the method of sample preparation.2. Ion SourceA liquid ion source was developed by Tsuchiya. Noda developed an electron bombardment type micro ion source. Okuyama improved ion emitters for FD ionization.3. Ionization MechanismTheoretical study of electron impact ionization was carried out by Yamamoto. Nakata studied the ionization mechanism of proton attachment.

1.生物医学高质量物质的质谱学研究介绍了Ohashi的离子束质谱技术。Suzuki研究了Na离子在西姆斯电离中的行为。Matsuo、Katakuse和Matsuda建立了分析血红蛋白变体的技术，并确定了几种新的变体结构。他们还测量了肽质谱中的质量分布。池川研究了样品纯化的方法.离子源Tsuchiya开发的液体离子源。野田开发了电子轰击型微离子源。Okuyama改进了FD电离的离子发射器。电离机制Yamamoto对电子碰撞电离进行了理论研究。Nakata研究了质子附着的电离机制。

项目成果

Y.Fujita;T.Matsuo;T.Sakurai;H.Matsuda;I.Katakuse: Int.J.Mass Spectrom.and Ion Proc.63. 231-240 (1985)

Y.Fujita；T.Matsuo；T.Sakurai；H.Matsuda；I.Katakuse：Int.J.质谱和离子过程 63。

I.Katakuse;T.Ichihara;H.Nakabushi;T.Matsuo;H.Matsuda: Mass Spectroscopy. 31. 111-114 (1983)

I.Katakuse；T.Ichihara；H.Nakabushi；T.Matsuo；H.Matsuda：质谱。

H.Nakata;Y.Hosino;N.Takeda;A.Takematsu: Org.Mass Spectrometry. 20(7). 467-470 (1985)

H.Nakata；Y.Hosino；N.Takeda；A.Takematsu：有机质谱。

T.Noda;T.Okutani;H.Tamura: J.Appl.Phys.54(9). 935-939 (1985)

T.Noda；T.Okutani；H.Tamura：J.Appl.Phys.54(9)。

M.Tsuchiya H.Kuwabara: Anal.Chem.56. 14-19 (1984)

M.Tsuchiya H.Kuwabara：Anal.Chem.56。