Analysis of the heat stress transcription factors network of Arabidopsis thaliana

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The complexity of the plant stress response systems correlates with an unusual multiplicity of regulatory proteins. Analysis of the Arabidopsis genome revealed the existence of 21 ORFs encoding heat stress transcription factors (Hsfs). The project aims at the comparative analysis of these Hsfs with respect to their expression patterns, activator functions, intracellular localization and above all their interaction with other Hsfs (heterooligomerization) or other regulatory proteins (coregulators). A central aspect will be the characterization of the complex promoter architecture of the Arabidopsis hs genes and the role of hsf combinations for efficient activation of these genes (synergism between Hsfs). The results from the first three years period will serve as a basis for more advanced investigations of the Hsf network and its cross talks with the general stress signalling pathways of plants.