Prevention of metabolic syndrome using food factors

利用食物因素预防代谢综合征

• 批准号: 18580133
• 负责人: TSUDA Takanori
• 金额: $ 2.52万
• 依托单位: Chubu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18580133/
• 关键词: metabolic syndrome; adiponectin; food factor; adipocyte; diabetes

Adipocyte dysfunction is strongly associated with the development of obesity and insulin resistance. It is accepted that the regulation of adipocytokine expression is one of the most important targets for the prevention of obesity and improvement of insulin sensitivity. In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type2 diabetic mice. These findings indicate that C3G has significant potency in an anti-diabetic effect through the regulation of Glut4-RBP4 system and the related inflammatory adipocytokines.

脂肪细胞功能障碍与肥胖和胰岛素抵抗的发生密切相关。目前认为，调节脂肪细胞因子的表达是预防肥胖和改善胰岛素敏感性的重要靶点之一。在这项研究中，我们证明了花青素(花青素)是一种广泛存在于植物界的色素，通过减少视黄醇结合蛋白4(RBP4)的表达来改善2型糖尿病小鼠的高血糖和胰岛素敏感性。这些结果表明，C3G通过调节GLUT4-RBP4系统和相关的炎性脂肪细胞因子而具有显著的抗糖尿病作用。

项目成果

Regulation of adipocyte function by anthocyanins; Possibility of preventing the metabolic syndrome

• DOI: 10.1021/jf073113b
• 发表时间: 2008-02-13
• 期刊: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
• 影响因子: 6.1
• 作者: Tsuda, Takanori

Microarray profiling of gene expression in human adiposytes in response to anthocyanins.

人类脂肪细胞响应花青素的基因表达的微阵列分析。

• 发表时间: 2006
• 期刊: Biochem. Pharmacol. 71
• 作者: Tsuda;T. et al.
• 通讯作者: T. et al.

Molecular mechanism for anti-diabetic Effect of anthocyanin

花青素抗糖尿病作用的分子机制

• 发表时间: 2007
• 作者: Sasaki;R.;et. al.
• 通讯作者: et. al.

Microarray profiling of gene expression in human adipocytes in response to anthocyanins

• DOI: 10.1016/j.bcp.2005.12.042
• 发表时间: 2006-04-14
• 期刊: BIOCHEMICAL PHARMACOLOGY
• 影响因子: 5.8
• 作者: Tsuda, T;Ueno, Y;Osawa, T
• 通讯作者: Osawa, T

Cyanidin 3-glucoside ameliorates hyperglycemia and, insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice

• DOI: 10.1016/j.bcp.2007.08.008
• 发表时间: 2007-12-03
• 期刊: BIOCHEMICAL PHARMACOLOGY
• 影响因子: 5.8
• 作者: Sasaki, Rie;Nishimura, Natsumi;Tsuda, Takanori
• 通讯作者: Tsuda, Takanori