Anti-diabetes and its mechanism using food factors via incretin action.

食物因素促进肠道L细胞内源性GLP-1的分泌是防治糖尿病的重要靶点之一。在本研究中，我们证明了黄色素姜黄素显著促进L细胞模型中GLP-1的分泌，并利用姜黄素的衍生物阐明了其构效关系。此外，在分泌机制方面，姜黄素显著增加GLP-1的分泌涉及CaMKII途径，而不依赖于细胞外信号调节激酶、PKC和cAMP/PKA相关途径。

Increase endogenous GLP-1 secretion from intestinal L cells by food factors is one of the crucial targets for prevention and treatment of diabetes. In the present study, we demonstrate that curcumin, a yellow pigment, significantly increases GLP-1 secretion in L cells model, and we clarified the structure activity relationship using curcumin derivatives. Also, concerning the secretory mechanism, the significant increase in GLP-1 secretion by curcumin involved the CaMKII pathway, and was independent of extracellular signal-regulated kinase, PKC, and the cAMP/PKA-related pathway.