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Investigation of the control mechanism of hypothalamo-limbic system through pheromone perceptive system

信息素感知系统对下丘脑边缘系统控制机制的研究

基本信息

批准号：
18580288
负责人：
TANIGUCHI Kazuyuki
金额：
$ 2.43万
依托单位：
Iwate University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18580288/
关键词：
veterinary medicine brain・nerve cell・tissue olfaction pheromone

项目摘要

The vomeronasal organ (VNO) is concerned with the pheromone perception, and its sensory neurons project to the accessory olfactory bulb. Neurons in the accessory olfactory bulb project via the amygdaloid body to the medial preoptic area of hypothalamus and control the secretion of sex hormones through GnRH neurons of the preoptic area. In addition, dopamine cells of the tubero-infundibular system are known to suppress the release of sex hormones from the adenohypophysis. These reports suggest that the removal of the VNO leads to the changes in the density and distribution of GnRH neurons and TH neurons of the hypothalamus and influences the reproduction control mechanism. Therefore, we removed the rat VNO and examined the immuniohistochemical changes of the LHRH and TH neurons in the hypothalamus. Rats were used at 64, 98 and 164 days after removal of the VNO. There were no significant differences in the distribution density of GnRh1- and GnRH3-positive cells and nerves between experimental and control groups. Removal of the VNO did not influence the distribution of TH-positive fibers in the olfactory tubercle and TH-positive cells and fibers around the third ventricle. Although GnRH neurons and TH neurons in the central nervous between experimental and control groups. Removal of the VNO did not influence the distribution of TH-positive fibers in the olfactory tubercle and TH-positive cells and fibers around the third ventricle. Although GnRH neurons and TH neurons in the central nervous system were not influenced by the removal of the VNO, GnRH3-positive nerves and fibers tended to increase slightly after the removal of the VNO. These findings suggest that the removal of the VNO did not influence the sex hormone secretory mechanism in the central nervous system of the rats over 64 days after removal of the VNO.

犁鼻器（VNO）与信息素的感知有关，其感觉神经元投射到副嗅球。副嗅球内的神经元经杏仁体投射至下丘脑内侧视前区，并通过视前区的GnRH神经元控制性激素的分泌。此外，已知结节漏斗系统的多巴胺细胞抑制腺垂体释放性激素。这些研究结果表明，VNO的去除导致下丘脑GnRH神经元和TH神经元的密度和分布发生变化，从而影响生殖控制机制。因此，我们去除大鼠VNO，并检查下丘脑LHRH和TH神经元的免疫组织化学变化。在去除VNO后64、98和164天使用大鼠。实验组和对照组之间GnRH1和GnRH3阳性细胞和神经的分布密度无显著性差异。去除VNO不影响嗅结节内TH阳性纤维和第三脑室周围TH阳性细胞和纤维的分布。虽然实验组和对照组之间的中枢神经GnRH神经元和TH神经元。去除VNO不影响嗅结节内TH阳性纤维和第三脑室周围TH阳性细胞和纤维的分布。虽然在中枢神经系统中的GnRH神经元和TH神经元不受VNO的去除的影响，GnRH 3阳性神经和纤维往往略有增加后，VNO的去除。这些结果表明，去除VNO后64天内，大鼠中枢神经系统的性激素分泌机制没有受到影响。