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Role of PrRP neurons in the control of food intake and emotional responses

PrRP 神经元在控制食物摄入和情绪反应中的作用

基本信息

批准号：
18590223
负责人：
ONAKA Tatsushi
金额：
$ 2.47万
依托单位：
Jichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Prolactin-releasing peptide (PrRP) is synthesized in the noradrenergic neurons of the medulla oblongata. We have previously shown that both a peripheral satiety signal, cholecystokinin octapeptide (CCK) and stressful stimuli activate noradrenergic neurons in the medulla oblongata The aim of this study is to investigate roles of PrRP in the control of food intake and stress responses. We firstly examined whether food intake activates PrRP neurons in the medulla oblongata. The percentage of PrRP neurons expressing pCREB was increased following CCK, suggesting that food intake activates PrRP neurons. Administration of and-PrRP neutralizing antibodies increased the amount of food intake per meal but not the meal frequency, as a result, increased the total amount of food intake per day. The data suggest that PrRP is a central satiety factor that mediates peripheral satiety signaling of CCK We then examined whether effects of PrRP in the control of emotional behavior. Administration of PrRP increased the number of entries into the open arms and the percentage of stay in the open aims of an elevated plus maze test, suggesting that PrRP has anxiolytic effects. Administration of anti-PrRP neutralizing antibodies had the opposite effects, suggesting that endogenous PrRP has anxiolytic actions. All these data are consistent with an idea that food intake activates PrRP neurons, as a result stops eating and reduces anxiety-related behavior.

催乳素释放肽（PrRP）在延髓的去肾上腺素能神经元中合成。我们之前已经证明，外周饱腹感信号、胆囊收缩素八肽（CCK）和应激刺激都能激活延髓中的去甲肾上腺素能神经元。本研究的目的是探讨PrRP在控制食物摄入和应激反应中的作用。我们首先研究了食物摄入是否激活延髓中的PrRP神经元。CCK后表达pCREB的PrRP神经元比例增加，提示食物摄入激活了PrRP神经元。使用and-PrRP中和抗体增加了每餐的食物摄入量，但没有增加用餐频率，因此，增加了每天的总食物摄入量。这些数据表明PrRP是介导CCK外周饱腹感信号的中心饱腹感因子。我们随后研究了PrRP是否在情绪行为控制中起作用。PrRP的使用增加了进入张开双臂的次数和在升高的迷宫测试中停留在张开目标的百分比，表明PrRP具有抗焦虑作用。给予抗PrRP中和抗体则有相反的效果，提示内源性PrRP具有抗焦虑作用。所有这些数据都与食物摄入激活PrRP神经元，从而停止进食并减少焦虑相关行为的观点相一致。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Centrally administered neuropeptide W-30 activatos magnocellular neurosecretory cellsin the supraoptic and paraventricular nucfei with neurosecretion in rats

集中施用神经肽 W-30 激活大鼠视上和室旁核中的大细胞神经分泌细胞并具有神经分泌作用

DOI：
发表时间：
2006
期刊：
J.Endocrinology 190
影响因子：
0
作者：
Kawasaki;M.
通讯作者：
M.

Roles of the hypotalamus and the brainstem in the control of food intake

下丘脑和脑干在控制食物摄入中的作用

DOI：
发表时间：
2008
期刊：
影响因子：
0
作者：
Onaka;T
通讯作者：
T

Possible inhibitory role of prolactin-releasing peptide for ACTH release associated with running stress

DOI：
10.1152/ajpregu.00345.2006
发表时间：
2007-01-01
期刊：
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
影响因子：
2.8
作者：
Ohiwa, Nao;Chang, Hyukki;Soya, Hideaki
通讯作者：
Soya, Hideaki

Possible inhibitory role of prolactin-releasing prptide for ACTH release associated with running stress.

催乳素释放肽对与跑步压力相关的 ACTH 释放可能具有抑制作用。