Analysis of the Molecular Pathology for the Salidonmide Syndrome

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Salidomide is a medicine which has anti-immune effect and anti-inflamation effect. Recently this medicine is applied for the treatment for several diseases. However it is also well-known to show the strong teratogenic effect for the embryo which is called Salidomide syndrome, which mechanism is still unclear. We planed the research to disclose the mechanism of the teratogenic effect of the salidomide. We have experience the molecular cloning of Roberts syndrome which is human genetic disease with phenotype of phocomelia, which resemble to the limb phenotype of salidomide syndrome. We analyze the salidomide died on the expression level of possible target genes using cultured cell line. We found suppressed expression of ESCO2 which is defect in Roberts syndrome which might suggest the part of mechanism of salidomide syndrome. Other research effort proved the cellular biological characteristics of Roberts patient lymphoblasts. They are sensitive to the mitomycine C than normal lymphoblast and has problem in spindle checkpoint. These result might lead the disclosure of salidomide side effect and suggest the treatment to inhibit the teratogenic effect