Spatiotemporal control of cell functions by Rho GTPases ; mechanisms and physiological roles

Rho GTPases 对细胞功能的时空控制；

• 批准号: 18002015
• 负责人: NARUMIYA Shuh
• 金额: $ 410.34万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Specially Promoted Research
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18002015/
• 关键词: Rho; アクチン; 微小管; 細胞周期; 細胞質分裂; mDia; ROCK; 個体発生; 癌化; 神経細胞; 細胞運動; 細胞骨格; Rho GTPase; 癌; 細胞分裂; Rho GTPases; ROCk; 細胞移動; 細胞接着; 免疫; がん; 神経; 遺伝子欠損マウス; 収縮環; 核輸送; がん化

The small GTPase Rho functions as a molecular switch of cell morphogenesis, adhesion, migration and division by acting on downstream signaling molecules. Here we studied the spatiotemoral role of this signaling in cultured cells and the body. We revealed the role and mechanism of the Rho signaling in cell migration and cell division in cultured cells and further found that this pathway plays an essential role in development such as embryo vasculogenesis and proper path finding of axon, and that this pathway is exploited by oncogenes in cell transformation and tumorigenesis.

小G T β Rho通过作用于下游信号分子，作为细胞形态发生、粘附、迁移和分裂的分子开关发挥作用。在这里，我们研究了这种信号在培养细胞和身体中的时空作用。我们揭示了Rho信号通路在培养细胞的细胞迁移和细胞分裂中的作用和机制，并进一步发现该通路在胚胎血管发生和轴突的正确路径发现等发育过程中起重要作用，并且该通路在细胞转化和肿瘤发生中被癌基因利用。

项目成果

Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.

• DOI: 10.1016/j.jneuroim.2009.01.015
• 发表时间: 2009-03-31
• 期刊: Journal of neuroimmunology
• 影响因子: 3.3
• 作者: Saleem S;Kim YT;Maruyama T;Narumiya S;Doré S
• 通讯作者: Doré S

Prostaglandin D2 Protects Neonatal Mouse Brain from Hypoxic Ischemic Injury

• DOI: 10.1523/jneurosci.0321-07.2007
• 发表时间: 2007-04
• 期刊: The Journal of Neuroscience
• 作者: Hidetoshi Taniguchi;I. Mohri;Hitomi Okabe-Arahori;K. Aritake;Kazuko Wada;T. Kanekiyo;S. Narumiya;M. Nakayama;K. Ozono;Y. Urade;M. Taniike

Prostaglandin E2 stimulates the production of amyloid beta peptides through internalization of the EP4 receptor.

前列腺素 E2 通过 EP4 受体的内化刺激β淀粉样肽的产生。

• 发表时间: 2009
• 期刊: J.Biol.Chem. 284
• 作者: Hoshino;T.;Namba;T.;Takehara;M.;Nakaya;T.;Sugimoto;Y.;Araki;W.;Narumiya;S.;Suzuki;T.;Mizushima;T.
• 通讯作者: T.

Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies.

• DOI: 10.1016/j.pharmthera.2010.09.004
• 发表时间: 2011-02
• 期刊: Pharmacology & therapeutics
• 影响因子: 13.5
• 作者: Koh-ichi Yuhki;Fumiaki Kojima;H. Kashiwagi;J. Kawabe;T. Fujino;S. Narumiya;F. Ushikubi

The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src

• DOI: 10.1128/mcb.00283-06
• 发表时间: 2006-09-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Yamana, Norikazu;Arakawa, Yoshiki;Narumiya, Shuh
• 通讯作者: Narumiya, Shuh