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Study of molecular basis for T cell-mediated recognition of antigens in subjects with HLA-A3 super type

HLA-A3超型受试者T细胞介导的抗原识别的分子基础研究

基本信息

批准号：
18310147
负责人：
ITOH Kyogo
金额：
$ 11.72万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18310147/
关键词：
cancer virus allergy biotechnology immunology

项目摘要

1. Cancer associated antigen-derived peptides: We have identified new peptides from SART3 and Lck antigens that are recognized by HLA-A3 super family-restricted cytotoxic T lymphocytes (CTL) (Minami, et. Al., Cancer Immunol. Immunoth.: Naito, et. Al., Brit.J.Can. 2007).2. Exogenous antigen-derived peptides: We have identified new peptides from hepatitis C virus sequences that are recognized by HLA-A3 super family-restricted CTL (Matsueda, et. Al., Cancer Immunol Immunotherapy, 2007). Furthermore, we found that measurement of lgG antibodies specific to core region of hepatitis C virus at positions 35-44 (C35-44) is a possible new diagnostic tool of hepatitis C virus infection (Takao, et. Al., Med. Mirobiol. Immunol., 2007).3. Self antigen-derived peptides: We have identified new peptides from self antigens that are recognized by HLA-A3 super family-restricted CTL (Matsueda, et. Al., J. Immunotherpy 2007).4. Summary: We have obtained new evidence during the past two years with regard to molecular basis of T cell-mediated recognition of antigens in both healthy donors and cancer patients belonging to HLA-A3 super type (HLA-A3,-A 11, -A31, and-A33). The binding motifs of these newly identified peptides to HLA-class IA alleles of HLA-A3 super type were mostly unpredictable from the currently available database of MHC binding peptides predicting the binding of peptides to HLA-class IA alleles of A3 super type. These results indicate that the binding motifs of CTL epitopes to HLA-class IA alleles of HLA-A3 super type are different form those expected in the past. The results created in this grant shall facilitate to better understanding of host responses to cancer cells as well as viral antigens in subjects of HLA-A3 super type, and may contribute to development of new database of MHC binding peptides.

1. 癌症相关抗原衍生多肽：我们已经从SART3和Lck抗原中鉴定出被HLA-A3超家族限制性细胞毒性T淋巴细胞（CTL）识别的新多肽（Minami等人，Cancer immuno1）。Immunoth。：内藤，et. Al.，英国。2007)。2。外源性抗原衍生多肽：我们已经从丙型肝炎病毒序列中鉴定出被HLA-A3超家族限制性CTL识别的新多肽（Matsueda等人，Cancer immunoimmunotherapy, 2007）。此外，我们发现测量35-44位（C35-44）的丙型肝炎病毒核心区域特异性lgG抗体可能是一种新的丙型肝炎病毒感染诊断工具（Takao等人，Med. Mirobiol）。Immunol。, 2007年)。3。自身抗原衍生肽：我们已经从自身抗原中鉴定出新的肽，这些肽被HLA-A3超家族限制性CTL识别（Matsueda, et. Al.， J. Immunotherpy 2007）。摘要：在过去两年中，我们获得了关于健康供体和属于HLA-A3超型（HLA-A3,- 11， -A31和- a33）的癌症患者中T细胞介导的抗原识别的分子基础的新证据。这些新鉴定的多肽与HLA-A3超型hla - IA类等位基因的结合基序，在目前可用的预测多肽与A3超型hla - IA类等位基因结合的MHC结合肽数据库中，大多是不可预测的。这些结果表明，CTL表位与HLA-A3超型hla - IA类等位基因的结合基序与以往的预期不同。本次资助的结果将有助于更好地了解HLA-A3超型患者对癌细胞和病毒抗原的宿主反应，并可能有助于建立新的MHC结合肽数据库。