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High-speed preparation of biocompatible ceramic coatings by laser CVD

激光CVD高速制备生物相容性陶瓷涂层

基本信息

批准号：
18360310
负责人：
GOTO Takashi
金额：
$ 10.64万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18360310/
关键词：
biocompatible ceramic coatings laser CVD

项目摘要

In the present study, calcium base oxides, e.g. CaTiO_3, α-TCP and HAp films were prepared by metalorganic chemical vapor deposition (MOCVD) and laser enhanced CVD (LCVD). Effects of preparation conditions on the crystal phase, microstructure and deposition rate were investigated. Furthermore, the bone conductivity and biocompatibility were evaluated by the formation behavior of apatite on those films in a Hanks'' solution.CaTiO_3, α-TCP and HAp films were obtained first by MOCVD. Apatite wholly covered the surface of CaTiO_3 films with a smooth surface after 6 weeks, CaTiO_3 films with a complicated surface after 3 days, α-TCP films after 2 weeks and HAp films after 6 hours. The apatite predominantly formed at the micro-sized hollows, indicating significant effect of surface morphology on the apatite formation rate except of the intrinsic bone conductivity of the ceramics films.HAp and α-TCP films were obtained also by LCVD at a high deposition rate. Laser power (P_L) showed significant effect on the crystal phase of Ca-P-O films: at P_L=200W α-TCP formed in wide conditions, at P_L=150W α-TCP formed at high temperatures and HAp formed at low temperatures, at P_L=100W HAp in a main phase formed in wide conditions. Any film showed a dense microstructure. The deposition rate increased with increasing the precursor concentration, deposition temperature, laser power and total pressure in chamber (P_<tot>), showing the highest value of 1200μm/h at P_L=200W and P_<tot>=0.6 kPa. Apatite formed on the Hap films prepared by LCVD in Hanks'' solution after 6 hours.In a summary, it is confirmed that CaTiO_3, α-TCP and HAp films can be prepared by chemical vapor deposition, and the effects of preparation conditions on the crystal phase, microstructure and deposition rate were clarified. The CaTiO_3, α-TCP and HAp films prepared by CVD were proved to have excellent bone conductivity by revealing high apatite formation rate in pseudo body solutions.

在本研究中，钙基氧化物，例如采用金属有机化学气相沉积(MOCVD)和激光增强CVD(LCVD)技术制备了CaTiO_3、α-TCP和HAp薄膜。研究了制备条件对晶相、显微结构和沉积速率的影响。并通过Hanks溶液中磷灰石的形成行为来评价其骨传导性和生物相容性。首先通过MOCVD获得了CaTiO_3、α-TCP和HAp薄膜。 6周后磷灰石完全覆盖了表面光滑的CaTiO_3薄膜，3天后磷灰石完全覆盖了表面复杂的CaTiO_3薄膜，2周后磷灰石完全覆盖了α-TCP薄膜，6小时后HAp薄膜被磷灰石完全覆盖。磷灰石主要在微米尺寸的空洞处形成，这表明除了陶瓷膜的固有骨传导性之外，表面形貌对磷灰石形成速率的显着影响。HAp和α-TCP膜也通过LCVD以高沉积速率获得。激光功率（P_L）对Ca-P-O薄膜的晶相影响显着：P_L=200W时，宽条件下形成α-TCP；P_L=150W时，高温下形成α-TCP，低温下形成HAp；P_L=100W时，宽条件下形成主相HAp。任何薄膜都显示出致密的微观结构。沉积速率随着前驱体浓度、沉积温度、激光功率和腔室总压(P_<tot>)的增加而增加，在P_L=200W和P_<tot>=0.6 kPa时显示出最高值1200μm/h。在Hanks溶液中LCVD制备的Hap薄膜6小时后形成磷灰石。综上所述,证实了化学气相沉积法可以制备CaTiO_3、α-TCP和HAp薄膜,并阐明了制备条件对晶相、显微结构和沉积速率的影响。 CVD制备的CaTiO_3、α-TCP和HAp薄膜在假体溶液中显示出较高的磷灰石形成率，证明具有优异的骨传导性。