Based on the relationship of macrophages-myofibroblasts, the pathogenesis of renal fibrosis and its therapeutic strategies

为了阐明肾纤维化导致慢性肾脏疾病的发病机制，我们对肾损伤组织中巨噬细胞和肌成纤维细胞的功能特性进行了病理研究。发现巨噬细胞出现异质，巨噬细胞产生的因子可诱导成肌纤维细胞。抑制巨噬细胞功能可改善肾纤维化。此外，对肝纤维化和伤口愈合纤维化进行比较病理学分析。

To clarify the pathogenesis of renal fibrosis leading to chronic renal disease, functional properties of macrophages and myofibroblasts appearing in kidney injured tissues were investigated pathologically. It was found that heterogeneous macrophages appeared, and that then factors produced by macrophages could induce myofibroblasts. Inhibition of macrophage functions may improve renal fibrosis. Additionally, hepatic fibrosis and wound healing fibrosis were analyzed comparative-pathologically.