Based on the relationship of macrophages-myofibroblasts, the pathogenesis of renal fibrosis and its therapeutic strategies

为了阐明肾纤维化导致慢性肾脏疾病的发病机制，对肾损伤组织中出现的巨噬细胞和肌成纤维细胞的功能特性进行了病理学研究。结果发现，在细胞内出现异质性巨噬细胞，巨噬细胞产生的因子可诱导成肌纤维细胞的形成。抑制巨噬细胞功能可改善肾纤维化。此外，对肝纤维化和伤口愈合纤维化进行了比较病理学分析。

To clarify the pathogenesis of renal fibrosis leading to chronic renal disease, functional properties of macrophages and myofibroblasts appearing in kidney injured tissues were investigated pathologically. It was found that heterogeneous macrophages appeared, and that then factors produced by macrophages could induce myofibroblasts. Inhibition of macrophage functions may improve renal fibrosis. Additionally, hepatic fibrosis and wound healing fibrosis were analyzed comparative-pathologically.