Development of an four-dimensional image-guided radiotherapy system

四维图像引导放射治疗系统的研制

• 批准号: 18390333
• 负责人: NAGATA Yasushi
• 金额: $ 8.52万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390333/
• 关键词: 4-dimensional treatment planning; radiotherapy; IGRT; respiratory gating; 4-d CT; stereotactic radiotherapy

To develop a new four-dimensional image-guided radiotherapy (IGRT) system, the following systems were developed.1. Four-dimensional treatment planning systemFour-dimensionally reconstructed CT images were obtained using MD-CT and gating signals. With these images, the movement of lung tumor could be more precisely evaluated.2. Respiratory gating systemThe relationship between the abdominal wall movement of a patient and lung tumor movement was evaluated. As a result, the correlation was so high (0.97). Therefore, the abdominal wall movement can be used as a surrogate signal for lung tumor.3. Clinical application of SBRTTwo-hundreds and thirty patients have been treated with SBRT technique. Ninety percent of high local control rates had been achieved for the patients with T1NOMO and T2NOMO tumor. Serious complications greater than CTCAE Grade 3 were 1.5%. The clinical results for the patients with pulmonary oligometastases were also promising.4. Development of an IGRT systemA new four-dimensional IGRT system was equipped with gimbaled X-ray system and ultralight C-band linear accelerator on a rigid 0-ring structure. The accuracy of the static beam positioning was 0.1mm.

为了开发新的四维图像引导放射疗法（IGRT）系统，开发了以下系统。1。使用MD-CT和门控信号获得了四维治疗计划SystemFour维度重建的CT图像。使用这些图像，可以更精确地评​​估肺部肿瘤的运动2。评估了患者的腹壁运动与肺部肿瘤运动之间的关系。结果，相关性如此之高（0.97）。因此，腹壁运动可用作肺部肿瘤的替代信号3。 SBRTTWO-HUNTWO和30名患者的临床应用已接受SBRT技术治疗。对于T1NOMO和T2NOMO肿瘤的患者，已经达到了局部高的局部控制率。大于CTCAE 3级的严重并发症为1.5％。患有肺部寡聚酶的患者的临床结果也很有希望。4。 IGRT Systema的开发新的四维IGRT系统配备了固定0环结构上的X射线系统和超轻C波段线性加速器。静态束定位的精度为0.1mm。

项目成果

体幹部定位照射の現況

立体定向全身照射现状

• 发表时间: 2008
• 作者: 新井誠;数藤由美子;Meerabux J;豊田倫子;大羽尚子;小幡菜々子;野原泉;大津嘉隆;柴田智行;古川愛造;吉川武男;糸川昌成.;松本英樹;永田 靖
• 通讯作者: 永田 靖

I期非小細胞肺癌に対する定位放射線治療

I期非小细胞肺癌的立体定向放射治疗

• 发表时间: 2005
• 期刊: 呼吸器科 (印刷中)
• 作者: Naoko Tsujita;Sachiko Goto;Yoshiharu Azuma et al.;新部 譲;Hayakawa K;新部 譲
• 通讯作者: 新部 譲

Characteristics of patients who developed radiation pneumonitis requiring steroid therapy after stereotactic irradiation for lung tumors

• DOI: 10.1097/00130404-200601000-00008
• 发表时间: 2006-01-01
• 期刊: CANCER JOURNAL
• 影响因子: 2.2
• 作者: Fujino, M;Shirato, H;Hiraoka, M
• 通讯作者: Hiraoka, M

Development of a four-dimensional image-guided radiotherapy system with a gimballed x-ray head.

开发带有万向 X 射线头的四维图像引导放射治疗系统。

• 发表时间: 2006
• 期刊: Int. J. Radiation Oncology Biol. Phys. 66
• 作者: Kamino Y;Takayama K;Kokubo M;Narita Y;Hirai E;Nagata Y;et. al.
• 通讯作者: et. al.

放射線治療-体幹部定位照射-化学放射線治療-

放射治疗 - 立体定向全身照射 - 放化疗 -

• 发表时间: 2006
• 作者: 細井義夫(分担) 大西洋;唐澤克之;唐澤久美子監修;永田 靖
• 通讯作者: 永田 靖