Development of a three-dimensional irradiation system for intensity-modulated radiotherapy and its clinical application.

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To establish an integrated three-dimensional irradiation system for IMRT (intensity-modurated radiotherapy), the following research had been performed.1. Respiratory gating systemTo expand the stereotactic radiotherapy for a patient with poor respiratory function, a gating system is ideal. In this study, a flow and a pressure gated signal generators was established for this purpose.2. Clinical application of stereotactic radiotherapyAs many as 95 patients have been treated with this technique. The clinical results of primary lung cancer and secondary lung cancer was evaluated respectively.3. Quality assurance of IMRTAn original phantom for the clinical application of IMRT for head and neck cancer was developed, and its quality assarance was performed. In general, the dose discrepancy was maintained within 5% between planned dose and measured dose.4. Clinical application of IMRTIMRT have been performed mainly for prostate cancer and head & neck cancers : The setup error was measured for prostate cancer, and the effect of metallic artifact and change in outline were evaluated for head and neck cancer.